Sorbs2 Modulation of BK Channels in Arterial Myocytes: Implications for Diabetes

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2024 Mar 28

PMID 38547252

Authors

L Fernando Santana

Manuel F Navedo

Affiliations

Soon will be listed here.

References

Nieves-Cintron M, Syed A, Buonarati O, Rigor R, Nystoriak M, Ghosh D . Impaired BK channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep. 2017; 7(1):14058. PMC: 5656614. DOI: 10.1038/s41598-017-14565-9. View

Sun X, Lee H, Lu T . Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes. Circ Res. 2024; 134(7):858-871. PMC: 10978258. DOI: 10.1161/CIRCRESAHA.123.323538. View

Martin-Aragon Baudel M, Flores-Tamez V, Hong J, Reddy G, Maillard P, Burns A . Spatiotemporal Control of Vascular Ca1.2 by α1 S1928 Phosphorylation. Circ Res. 2022; 131(12):1018-1033. PMC: 9722584. DOI: 10.1161/CIRCRESAHA.122.321479. View

Nelson M, Cheng H, Rubart M, Santana L, Bonev A, Knot H . Relaxation of arterial smooth muscle by calcium sparks. Science. 1995; 270(5236):633-7. DOI: 10.1126/science.270.5236.633. View

Spassova M, Hewavitharana T, Xu W, Soboloff J, Gill D . A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A. 2006; 103(44):16586-91. PMC: 1637625. DOI: 10.1073/pnas.0606894103. View

Tan Y, Ichikawa T, Li J, Si Q, Yang H, Chen X . Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes. 2011; 60(2):625-33. PMC: 3028364. DOI: 10.2337/db10-1164. View

Santana L, Navedo M . Molecular and biophysical mechanisms of Ca2+ sparklets in smooth muscle. J Mol Cell Cardiol. 2009; 47(4):436-44. PMC: 2739251. DOI: 10.1016/j.yjmcc.2009.07.008. View

Gonzales A, Yang Y, Sullivan M, Sanders L, Dabertrand F, Hill-Eubanks D . A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries. Sci Signal. 2014; 7(327):ra49. PMC: 4170587. DOI: 10.1126/scisignal.2004732. View

Bulley S, Fernandez-Pena C, Hasan R, Leo M, Muralidharan P, MacKay C . Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. Elife. 2018; 7. PMC: 6281320. DOI: 10.7554/eLife.42628. View

10.

Knot H, Nelson M . Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol. 1998; 508 ( Pt 1):199-209. PMC: 2230857. DOI: 10.1111/j.1469-7793.1998.199br.x. View

11.

Nieves-Cintron M, Flores-Tamez V, Le T, Martin-Aragon Baudel M, Navedo M . Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle. Cell Mol Life Sci. 2020; 78(1):31-61. PMC: 7765743. DOI: 10.1007/s00018-020-03582-z. View

12.

Lu T, Sun X, Li Y, Chai Q, Wang X, Lee H . Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice. Diabetes. 2017; 66(10):2681-2690. PMC: 5606315. DOI: 10.2337/db17-0181. View

13.

Nystoriak M, Nieves-Cintron M, Nygren P, Hinke S, Nichols C, Chen C . AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2013; 114(4):607-15. PMC: 3954117. DOI: 10.1161/CIRCRESAHA.114.302168. View