Cryosphere: a Frozen Home of Microbes and a Potential Source for Drug Discovery

Overview

Journal Arch Microbiol

Specialty Microbiology

Date 2024 Mar 28

PMID 38546887

Authors

Sahib Zada

Mohsin Khan

Zheng Su

Wasim Sajjad

Muhammad Rafiq

Affiliations

Soon will be listed here.

Abstract

The world is concerned about the emergence of pathogens and the occurrence and spread of antibiotic resistance among pathogens. Drug development requires time to combat these issues. Consequently, drug development from natural sources is unavoidable. Cryosphere represents a gigantic source of microbes that could be the bioprospecting source of natural products with unique scaffolds as molecules or drug templates. This review focuses on the novel source of drug discovery and cryospheric environments as a potential source for microbial metabolites having potential medicinal applications. Furthermore, the problems encountered in discovering metabolites from cold-adapted microbes and their resolutions are discussed. By adopting modern practical approaches, the discovery of bioactive compounds might fulfill the demand for new drug development.

References

Afra S, Makhdoumi A, Matin M, Feizy J . A novel red pigment from marine Arthrobacter sp. G20 with specific anticancer activity. J Appl Microbiol. 2017; 123(5):1228-1236. DOI: 10.1111/jam.13576. View

Ali B, Sajjad W, Sharma Ghimire P, Shengyun C, Minghui W, Kang S . Culture-dependent diversity of bacteria from Laohugou glacier, Qilian Mts., China and their resistance against metals. J Basic Microbiol. 2019; 59(11):1065-1081. DOI: 10.1002/jobm.201900385. View

Allen H, Donato J, Wang H, Cloud-Hansen K, Davies J, Handelsman J . Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol. 2010; 8(4):251-9. DOI: 10.1038/nrmicro2312. View

Danquah C, Minkah P, Osei Duah Junior I, Amankwah K, Somuah S . Antimicrobial Compounds from Microorganisms. Antibiotics (Basel). 2022; 11(3). PMC: 8944786. DOI: 10.3390/antibiotics11030285. View

Anesio A, Laybourn-Parry J . Glaciers and ice sheets as a biome. Trends Ecol Evol. 2011; 27(4):219-25. DOI: 10.1016/j.tree.2011.09.012. View

Appleton D, Chuen C, Berridge M, Webb V, Copp B . Rossinones A and B, biologically active meroterpenoids from the Antarctic ascidian, Aplidium species. J Org Chem. 2009; 74(23):9195-8. DOI: 10.1021/jo901846j. View

Ayuso-Sacido A, Genilloud O . New PCR primers for the screening of NRPS and PKS-I systems in actinomycetes: detection and distribution of these biosynthetic gene sequences in major taxonomic groups. Microb Ecol. 2004; 49(1):10-24. DOI: 10.1007/s00248-004-0249-6. View

Bringmann G, Lang G, Maksimenka K, Hamm A, Gulder T, Dieter A . Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14. Phytochemistry. 2005; 66(11):1366-73. DOI: 10.1016/j.phytochem.2005.04.010. View

Brunati M, Rojas J, Sponga F, Ciciliato I, Losi D, Gottlich E . Diversity and pharmaceutical screening of fungi from benthic mats of Antarctic lakes. Mar Genomics. 2011; 2(1):43-50. DOI: 10.1016/j.margen.2009.04.002. View

10.

Bumol T, Watanabe A . Genetic information, genomic technologies, and the future of drug discovery. JAMA. 2001; 285(5):551-5. DOI: 10.1001/jama.285.5.551. View

11.

Cabanel N, Leclercq A, Chenal-Francisque V, Annajar B, Rajerison M, Bekkhoucha S . Plague outbreak in Libya, 2009, unrelated to plague in Algeria. Emerg Infect Dis. 2013; 19(2):230-6. PMC: 3559055. DOI: 10.3201/eid1902.121031. View

12.

Cameron K, Hodson A, Osborn A . Structure and diversity of bacterial, eukaryotic and archaeal communities in glacial cryoconite holes from the Arctic and the Antarctic. FEMS Microbiol Ecol. 2011; 82(2):254-67. DOI: 10.1111/j.1574-6941.2011.01277.x. View

13.

Carroll P, Dougherty B, Ross-Macdonald P, Browman K, FitzGerald K . Model systems in drug discovery: chemical genetics meets genomics. Pharmacol Ther. 2003; 99(2):183-220. DOI: 10.1016/s0163-7258(03)00059-7. View

14.

Charlier P, Claverie J, Sansonetti P, Coppens Y, Augias A, Jacqueline S . Re-emerging infectious diseases from the past: Hysteria or real risk?. Eur J Intern Med. 2017; 44:28-30. DOI: 10.1016/j.ejim.2017.06.018. View

15.

Chaturvedi P, Shivaji S . Exiguobacterium indicum sp. nov., a psychrophilic bacterium from the Hamta glacier of the Himalayan mountain ranges of India. Int J Syst Evol Microbiol. 2006; 56(Pt 12):2765-2770. DOI: 10.1099/ijs.0.64508-0. View

16.

Chavali A, DAuria K, Hewlett E, Pearson R, Papin J . A metabolic network approach for the identification and prioritization of antimicrobial drug targets. Trends Microbiol. 2012; 20(3):113-23. PMC: 3299924. DOI: 10.1016/j.tim.2011.12.004. View

17.

Chen D, Hackbarth C, Ni Z, Wu C, Wang W, Jain R . Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. Antimicrob Agents Chemother. 2003; 48(1):250-61. PMC: 310177. DOI: 10.1128/AAC.48.1.250-261.2004. View

18.

Chen J, Shi Q, Wang Y, Li Z, Wang S . Dereplication of known nucleobase and nucleoside compounds in natural product extracts by capillary electrophoresis-high resolution mass spectrometry. Molecules. 2015; 20(4):5423-37. PMC: 6272742. DOI: 10.3390/molecules20045423. View

19.

Christner B, Kvitko 2nd B, Reeve J . Molecular identification of bacteria and Eukarya inhabiting an Antarctic cryoconite hole. Extremophiles. 2003; 7(3):177-83. DOI: 10.1007/s00792-002-0309-0. View

20.

Cutler S, Fooks A, van der Poel W . Public health threat of new, reemerging, and neglected zoonoses in the industrialized world. Emerg Infect Dis. 2009; 16(1):1-7. PMC: 2874344. DOI: 10.3201/eid1601.081467. View