Lactate Drives CD38 Signaling to Promote Epithelial-Mesenchymal Transition Through Snail Induction in Non-small Cell Lung Cancer Cells

Overview

Journal J Cell Commun Signal

Date 2024 Mar 28

PMID 38545257

Authors

YaTing Lu

Yang Yang

Tao Chang

Qiyun Jiang

Chenfeng Yang

Chunzhe Fu

Huijun Wei

Yuanpeng He

Zhihao Wu

Affiliations

Soon will be listed here.

Abstract

CD38 is the main NADase in mammalian cells. It regulates the homeostasis of nicotinamide adenine dinucleotide (NAD+) and extracellular nucleotides. Its function plays an important role in infection and aging. However, its potential functions in tumor cells have not been fully elucidated. In the present study, we demonstrated that lactate, which is derived from tumor metabolism remodeling, upregulates the expression of CD38 through OXPHOS-driven Hippo-TAZ pathway. The highly expressed CD38 converts NAD + to adenosine through the CD203a/CD73 complex and adenosine binds and activates its receptor A2AR, inducing the expression of Snail and promoting the invasion and metastasis of lung cancer cells. This finding elucidates a new perspective on the interplay between NAD + metabolism and glycolysis in tumor development.

Citing Articles

Epithelial-mesenchymal plasticity in cancer: signaling pathways and therapeutic targets.

Wang X, Xue X, Pang M, Yu L, Qian J, Li X MedComm (2020). 2024; 5(8):e659.

PMID: 39092293 PMC: 11292400. DOI: 10.1002/mco2.659.

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