ABO and RhD Blood Groups and Their Relationship with Diseases: A Retrospective Study

Overview

Journal Pak J Med Sci

Specialty General Medicine

Date 2024 Mar 28

PMID 38545004

Authors

Olgun Goktas

Affiliations

Soon will be listed here.

Abstract

Objective: To retrospectively evaluate the distribution of ABO and RhD blood groups and their relationship with diseases.

Methods: The retrospective study was carried out in Bursa Uludag University Family Health Center in Turkey between 1-28 February, 2023. The data of individuals who were registered with the Family Health Center and whose blood types were known were evaluated retrospectively. Blood group type, sociodemographic findings, existing diseases, allergies, and genetic disease conditions were obtained. below 0.05 were considered statistically significant. Analysis were made in the SPSS 25.0 program.

Results: A total of 3834 people, 1935 male (50.5%) and 1899 female (49.5%) participated in the study. The mean age of the individuals was 26.45±10.45 years. About 75.8 percent of the participants were university students, 6.3 percent were health workers, and 17.9 percent were from other occupational groups. The rates of blood groups were determined as O Rh D+ at 33.5%, AB Rh D+ at 26.9%, A Rh D+ at 14.9%, AB Rh D- at 7.7%, B Rh D+ at 7%, O Rh D- at 4.6%, B Rh D- at 3.2% and A Rh D- at 2.2%. It was determined that the O Rh D- group had a higher rate of genetic disease than the other groups (p=0.01).

Conclusion: It was determined that the O Rh D+ blood group was found more frequently in our region's population than in other groups. This different result depending on the A Rh D+ blood group, which is the most common throughout the country may have reflected the influence of different geographical regions and ethnic characteristics due to the students in our population. In addition, the results regarding the relationships between blood groups and occupation, genetics, existing disease, presence of allergies, and visual defects in the eye are important.

References

SANGHVI L . ABO blood groups and sex-ratio at birth in man. Nature. 1951; 168(4288):1077. DOI: 10.1038/1681077a0. View

. BLOOD groups and diseases. Br Med J. 1956; 2(4995):757-8. PMC: 2035400. View

Yousuf F, Azam I, Tareen A, Kazmi K, Muhammad J, Iqbal M . Association of the BB genotype of the ABO gene with the risk of acute myocardial infarction in hospital-based study. Pak J Med Sci. 2023; 39(1):133-138. PMC: 9843019. DOI: 10.12669/pjms.39.1.5905. View

Sharif S, Anwar N, Farasat T, Naz S . ABO blood group frequency in Ischemic heart disease patients in Pakistani population. Pak J Med Sci. 2014; 30(3):593-5. PMC: 4048513. DOI: 10.12669/pjms.303.4502. View

Cooling L . Blood Groups in Infection and Host Susceptibility. Clin Microbiol Rev. 2015; 28(3):801-70. PMC: 4475644. DOI: 10.1128/CMR.00109-14. View

Jawed S, Atta K, Tariq S, Amir F . How good is the obesity associated with blood groups in a cohort of female university going students?. Pak J Med Sci. 2018; 34(2):452-456. PMC: 5954396. DOI: 10.12669/pjms.342.13633. View

Liu J, Zhang S, Wang Q, Shen H, Zhang Y, Liu M . Frequencies and ethnic distribution of ABO and RhD blood groups in China: a population-based cross-sectional study. BMJ Open. 2017; 7(12):e018476. PMC: 5736034. DOI: 10.1136/bmjopen-2017-018476. View

Westhoff C . Blood group genotyping. Blood. 2019; 133(17):1814-1820. DOI: 10.1182/blood-2018-11-833954. View

Falsarella N, Ferreira A, Nakashima F, Brandao de Mattos C, de Mattos L . Evidence of an association between the O blood group and allergic rhinitis. Rev Bras Hematol Hemoter. 2012; 33(6):444-8. PMC: 3459380. DOI: 10.5581/1516-8484.20110120. View

10.

Ewald D, Sumner S . Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016; 8(6):517-535. PMC: 5061611. DOI: 10.1002/wsbm.1355. View

11.

Saboor M, Ullah A, Qamar K, Mir A, Moinuddin . Frequency of ABH secretors and non secretors: A cross sectional study in Karachi. Pak J Med Sci. 2014; 30(1):189-93. PMC: 3955570. DOI: 10.12669/pjms.301.4194. View

12.

Nazli R, Haider J, Khan M, Akhtar T, Aslam H . Frequency of ABO blood groups and RhD factor in the female population of District Peshawar. Pak J Med Sci. 2015; 31(4):984-6. PMC: 4590353. DOI: 10.12669/pjms.314.6640. View

13.

Shah S, Arshad N, Asim F, Nadeem M . Prediction of Covid-19 infection severity using ABO blood group types and Rh factor. Pak J Med Sci. 2022; 38(7):1870-1876. PMC: 9532659. DOI: 10.12669/pjms.38.7.5128. View

14.

Mohamud M, Aweis A, Adam A, Mohamed F, Fidow S, Mohamed L . Distribution and Frequency of ABO and Rhesus (D) Blood Groups in Somalia: A Retrospective Study on Students of Jazeera University, Mogadishu-Somalia. Biomed Res Int. 2022; 2022:7981325. PMC: 8818412. DOI: 10.1155/2022/7981325. View

15.

Anwar M, Ali N, Khattak M, Raashid Y, Karamat K . A case for comprehensive antenatal screening for blood group antibodies. J Pak Med Assoc. 2000; 49(10):246-8. View

16.

Dahalan N, Tuan Din S, Mohamad S . Association of ABO blood groups with allergic diseases: a scoping review. BMJ Open. 2020; 10(2):e029559. PMC: 7045263. DOI: 10.1136/bmjopen-2019-029559. View

17.

Anstee D . The relationship between blood groups and disease. Blood. 2010; 115(23):4635-43. DOI: 10.1182/blood-2010-01-261859. View

18.

Rizzo C, Caruso C, Vasto S . Possible role of ABO system in age-related diseases and longevity: a narrative review. Immun Ageing. 2014; 11:16. PMC: 4265994. DOI: 10.1186/1742-4933-11-16. View

19.

Yousuf F, Kazmi K, Iqbal J, Ahmed N, Iqbal M . Higher DNA methylation of ABO gene promoter is associated with acute myocardial infarction in a hospital-based population in Karachi. Pak J Med Sci. 2020; 36(3):505-510. PMC: 7150418. DOI: 10.12669/pjms.36.3.1406. View

20.

JOHNSTONE J . Sex ratio and the ABO blood group system. Br J Prev Soc Med. 1954; 8(3):124-7. PMC: 1058546. DOI: 10.1136/jech.8.3.124. View