Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight As a Novel Modality in Diabetes Management

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Mar 28

PMID 38542928

Authors

Fahrul Nurkolis

Rudy Kurniawan

Elvan Wiyarta

Rony Abdi Syahputra

Reggie Surya

Nurpudji Astuti Taslim

Trina Ekawati Tallei

Raymond Rubianto Tjandrawinata

Eli Y Adashi

Bonglee Kim

Affiliations

Soon will be listed here.

Abstract

Diabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a pivotal role in regulating glucose levels in the body by aiding glucose uptake and storage in cells, and what happens to diabetes? In diabetes, there is a disruption and malfunction in insulin regulation. Despite numerous efforts, effectively addressing diabetes remains a challenge. This article explores the potential of photoactivatable drugs in diabetes treatment, with a focus on light-activated insulin. We discuss its advantages and significant implications. This article is expected to enrich the existing literature substantially, offering a comprehensive analysis of potential strategies for improving diabetes management. With its minimal physical intrusion, light-activated insulin promises to improve patient comfort and treatment adherence. It offers precise regulation and localized impact, potentially mitigating the risks associated with conventional diabetes treatments. Additionally, light-activated insulin is capable of explicitly targeting RNA and epigenetic factors. This innovative approach may pave the way for more personalized and effective diabetes treatments, addressing not only the symptoms but also the underlying biological causes of the disease. The advancement of light-activated insulin could revolutionize diabetes management. This study represents a pioneering introduction to this novel modality for diabetes management.

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