CDCA5 Promoted Cell Invasion and Migration by Activating TGF-β1 Pathway in Human Ovarian Cancer Cells

Overview

Journal J Ovarian Res

Publisher Biomed Central

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2024 Mar 28

PMID 38539247

Authors

Qingsong Zhang

Rong Zhang

Yuzhi Li

Xiaojun Yang

Affiliations

Soon will be listed here.

Abstract

Background: The gene cell division cycle associated 5 (CDCA5), also called sororin, has oncogenic characteristics and is upregulated in various carcinomas. Nevertheless, the involvement of CDCA5 in ovarian cancer (OC), a highly aggressive form of cancer, and the underlying mechanism of metastasis remain inadequately investigated.

Results: The bioinformatics data revealed a negative correlation between the patient's survival and CDCA5 expression, which was overexpressed in OC. Functional assays also confirmed high expression levels of CDCA5 in OC tissues and cells. This suggests that CDCA5 may potentially enhance the motility, migration, and proliferation of OC cells invitro. It impedes DNA damage and apoptosis in OC cells, inhibiting xenograft development in nude mice. The RNA sequencing results suggest CDCA5 is majorly associated with biological functions related to the extracellular matrix (ECM) and influences the transforming growth factor (TGF) signaling pathway. Moreover, subsequent functional investigations elucidated that CDCA5 facilitated the migration and invasion of OC cells viathe TGF-β1/Smad2/3 signaling pathway activation.

Conclusions: CDCA5 may be a strong potential therapeutic target for the treatment and management of OC.

Citing Articles

E2F1-Dependent CDCA5 overexpression drives cervical cancer progression and correlates with poor prognosis.

Wang Y, Zhang W, Peng M J Mol Histol. 2025; 56(2):80.

PMID: 39907709 DOI: 10.1007/s10735-025-10356-z.

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