Clonal Hematopoiesis: The Emergent CVD Risk Factor

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2024 Mar 27

PMID 38536898

Authors

Jesse D Cochran

Kenneth Walsh

Affiliations

Soon will be listed here.

Citing Articles

Clonal Hematopoiesis Is Associated With Adverse Clinical Outcomes and Left Ventricular Remodeling in Aortic Stenosis.

Yao C, Ko T, Yang L, Takeuchi M, Yeh C, Lin M JACC Adv. 2025; 4(2):101532.

PMID: 39886300 PMC: 11780101. DOI: 10.1016/j.jacadv.2024.101532.

References

Dhingra R, Vasan R . Age as a risk factor. Med Clin North Am. 2012; 96(1):87-91. PMC: 3297980. DOI: 10.1016/j.mcna.2011.11.003. View

Ridker P, MacFadyen J, Everett B, Libby P, Thuren T, Glynn R . Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial. Lancet. 2017; 391(10118):319-328. DOI: 10.1016/S0140-6736(17)32814-3. View

Gumuser E, Schuermans A, Cho S, Sporn Z, Uddin M, Paruchuri K . Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease. J Am Coll Cardiol. 2023; 81(20):1996-2009. PMC: 10249057. DOI: 10.1016/j.jacc.2023.03.401. View

Pascual-Figal D, Bayes-Genis A, Diez-Diez M, Hernandez-Vicente A, Vazquez-Andres D, de la Barrera J . Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction. J Am Coll Cardiol. 2021; 77(14):1747-1759. DOI: 10.1016/j.jacc.2021.02.028. View

Fuster J, MacLauchlan S, Zuriaga M, Polackal M, Ostriker A, Chakraborty R . Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017; 355(6327):842-847. PMC: 5542057. DOI: 10.1126/science.aag1381. View

Ridker P, Everett B, Thuren T, MacFadyen J, Chang W, Ballantyne C . Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med. 2017; 377(12):1119-1131. DOI: 10.1056/NEJMoa1707914. View

Bohme M, Desch S, Rosolowski M, Scholz M, Krohn K, Buttner P . Impact of Clonal Hematopoiesis in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction. J Am Coll Cardiol. 2022; 80(16):1545-1556. DOI: 10.1016/j.jacc.2022.08.740. View

Shi C, Aboumsallem J, Suthahar N, de Graaf A, Jansen J, van Zeventer I . Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers. Eur J Heart Fail. 2022; 25(1):4-13. PMC: 10092539. DOI: 10.1002/ejhf.2715. View

Genovese G, Kahler A, Handsaker R, Lindberg J, Rose S, Bakhoum S . Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014; 371(26):2477-87. PMC: 4290021. DOI: 10.1056/NEJMoa1409405. View

10.

Khot U, Khot M, Bajzer C, Sapp S, Ohman E, Brener S . Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003; 290(7):898-904. DOI: 10.1001/jama.290.7.898. View

11.

Ridker P, Libby P, MacFadyen J, Thuren T, Ballantyne C, Fonseca F . Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Eur Heart J. 2018; 39(38):3499-3507. DOI: 10.1093/eurheartj/ehy310. View

12.

Evans M, Walsh K . Clonal hematopoiesis, somatic mosaicism, and age-associated disease. Physiol Rev. 2022; 103(1):649-716. PMC: 9639777. DOI: 10.1152/physrev.00004.2022. View

13.

Yu B, Roberts M, Raffield L, Zekavat S, Nguyen N, Biggs M . Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure. J Am Coll Cardiol. 2021; 78(1):42-52. PMC: 8313294. DOI: 10.1016/j.jacc.2021.04.085. View

14.

Jaiswal S, Natarajan P, Silver A, Gibson C, Bick A, Shvartz E . Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N Engl J Med. 2017; 377(2):111-121. PMC: 6717509. DOI: 10.1056/NEJMoa1701719. View

15.

Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M . Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome. J Am Coll Cardiol. 2018; 71(8):875-886. PMC: 5828038. DOI: 10.1016/j.jacc.2017.12.037. View

16.

Akhiyat N, Lasho T, Ganji M, Toya T, Shi C, Chen X . Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nonobstructive Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2023; 43(5):774-783. PMC: 10133092. DOI: 10.1161/ATVBAHA.122.318928. View

17.

Toldo S, Mezzaroma E, Buckley L, Potere N, Di Nisio M, Biondi-Zoccai G . Targeting the NLRP3 inflammasome in cardiovascular diseases. Pharmacol Ther. 2021; 236:108053. PMC: 9187780. DOI: 10.1016/j.pharmthera.2021.108053. View

18.

Cochran J, Yura Y, Thel M, Doviak H, Polizio A, Arai Y . Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction. Circulation. 2023; 148(15):1165-1178. PMC: 10575571. DOI: 10.1161/CIRCULATIONAHA.123.064170. View

19.

Bhattacharya R, Zekavat S, Haessler J, Fornage M, Raffield L, Uddin M . Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Stroke. 2021; 53(3):788-797. PMC: 8885769. DOI: 10.1161/STROKEAHA.121.037388. View

20.

Kiefer K, Cremer S, Pardali E, Assmus B, Abou-El-Ardat K, Kirschbaum K . Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. ESC Heart Fail. 2021; 8(3):1873-1884. PMC: 8120376. DOI: 10.1002/ehf2.13297. View