Triglyceride-glucose Index Predicts Major Adverse Cardiovascular Events in Patients with Chronic Kidney Disease

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2024 Mar 27

PMID 38536621

Authors

Kangbo Li

Qiqi Hou

Xinyi Li

Liying Tian

Liyan Wang

Shouling Wu

Quanle Han

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Triglyceride-glucose (TyG) index has been regarded as a reliable surrogate marker of insulin resistance for predicting cardiovascular outcomes. The current study aimed to explore the associations between TyG index with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD).

Methods/patients: 13,517 patients with chronic kidney disease (CKD) from the Kailuan study were included. Patients were divided into quartiles according to the TyG index. The outcomes were MACE, including acute myocardial infarction (AMI) and ischemic stroke (IS). The association between TyG index and the risk of MACE was analyzed by Cox regression models.

Results: During 13.87-year follow-up, a total 1356 MACEs occurred. Multivariable Cox proportional-hazards analyses showed that a higher TyG index quartile was associated with an elevated risk of MACE.

Conclusions: TyG index is significantly related to MACE in patients with CKD. TyG index can be regarded as a novel predictor of MACE for patients with CKD.

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