Reproductive Enhancement Through Phytochemical Characteristics and Biological Activities of Date Palm Pollen: A Comprehensive Review on Potential Mechanism Pathways

Overview

Journal Metabolites

Publisher MDPI

Date 2024 Mar 27

PMID 38535326

Authors

Saad Salhi

Abdellatif Rahim

Mouad Chentouf

Hasnaa Harrak

Jean Loup Bister

Naima Hamidallah

Bouchra El Amiri

Affiliations

Soon will be listed here.

Abstract

Infertility represents a significant global health challenge affecting both men and women. Despite regular unprotected sexual intercourse, approximately 15% of couples of reproductive age struggle to conceive within 12 months, with 10% of infertility cases attributed to unknown causes worldwide. As a result, numerous studies have turned their attention to exploring the use of natural products for the prevention and treatment of infertility. Among these natural remedies is date palm pollen (DPP), a male reproductive powder derived from the blossoms of the L. palm tree, which has a long history of use as a dietary supplement, particularly as an aphrodisiac and fertility enhancer for both men and women. This review critically examines the diverse components of DPP, including metabolites, proteins, amino acids, fatty acids, to elucidate its potential impact on human reproduction. The analysis thoroughly assesses the composition of DPP in relation to its effects on enhancing reproductive processes and delves into its traditional uses and therapeutic benefits in male fertility, such as the enhancement of sexual desire, semen quality, and hormonal equilibrium. Similarly, it explores the influence of DPP on female fertility, emphasizing its potential to improve factors such as lubrication, desire, ovulation, and hormonal balance. Overall, this review underscores the potential of DPP as a natural remedy for addressing reproductive disorders.

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References

Mohd Mutalip S, Ab-Rahim S, Rajikin M . Vitamin E as an Antioxidant in Female Reproductive Health. Antioxidants (Basel). 2018; 7(2). PMC: 5836012. DOI: 10.3390/antiox7020022. View

Chen L, Shi G, Huang D, Li Y, Ma C, Shi M . Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention. Biomed Pharmacother. 2019; 112:108585. DOI: 10.1016/j.biopha.2019.01.046. View

Hooshang H, Farahani A, Rezaeizadeh H, Forouzannia S, Alaeddini F, Ashraf H . Efficacy of Date Palm Pollen in the Male Sexual Dysfunction after Coronary Artery Bypass Graft: A Randomized, Double-Blind, Clinical Trial. Evid Based Complement Alternat Med. 2022; 2022:5032681. PMC: 8979683. DOI: 10.1155/2022/5032681. View

Yang S, Pyo M, Nam M, Lee K . ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress. BMC Complement Altern Med. 2019; 19(1):139. PMC: 6585055. DOI: 10.1186/s12906-019-2551-3. View

Ugwuja E, Ugwu N, Ejikeme B . Prevalence of low sperm count and abnormal semen parameters in male partners of women consulting at infertility clinic in Abakaliki, Nigeria. Afr J Reprod Health. 2010; 12(1):67-73. View

Ferlin A, Foresta C . New genetic markers for male infertility. Curr Opin Obstet Gynecol. 2014; 26(3):193-8. DOI: 10.1097/GCO.0000000000000061. View

Tahvilzadeh M, Hajimahmoodi M, Rahimi R . The Role of Date Palm (Phoenix dactylifera L) Pollen in Fertility: A Comprehensive Review of Current Evidence. J Evid Based Complementary Altern Med. 2015; 21(4):320-4. DOI: 10.1177/2156587215609851. View

Ito T, Trant A, Polan M . A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J Sex Marital Ther. 2001; 27(5):541-9. DOI: 10.1080/713846828. View

Saleh M, Kokoszynski D, Mousa M, Abuoghaba A . Effect of Date Palm Pollen Supplementation on the Egg Production, Ovarian Follicles Development, Hematological Variables and Hormonal Profile of Laying Hens. Animals (Basel). 2021; 11(1). PMC: 7830308. DOI: 10.3390/ani11010069. View

10.

Fallahi S, Rajaei M, Hesam M, Koolivand M, Malekzadeh K . The effect of pollen on the expression of , and genes, and sperm parameters of fertile and infertile men: A controlled clinical trial. Int J Reprod Biomed. 2021; 19(6):545-558. PMC: 8350849. DOI: 10.18502/ijrm.v19i6.9376. View

11.

Selmani C, Chabane D, Bouguedoura N . ETHNOBOTANICAL SURVEY OF L. POLLEN USED FOR THE TREATMENT OF INFERTILITY PROBLEMS IN ALGERIAN OASES. Afr J Tradit Complement Altern Med. 2017; 14(3):175-186. PMC: 5412223. DOI: 10.21010/ajtcam.v14i3.19. View

12.

Ahmed W, Feyissa T, Tesfaye K, Farrakh S . Genetic diversity and population structure of date palms (Phoenix dactylifera L.) in Ethiopia using microsatellite markers. J Genet Eng Biotechnol. 2021; 19(1):64. PMC: 8105468. DOI: 10.1186/s43141-021-00168-5. View

13.

Gauthaman K, Ganesan A . The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat. Phytomedicine. 2007; 15(1-2):44-54. DOI: 10.1016/j.phymed.2007.11.011. View

14.

Collodel G, Castellini C, Lee J, Signorini C . Relevance of Fatty Acids to Sperm Maturation and Quality. Oxid Med Cell Longev. 2020; 2020:7038124. PMC: 7025069. DOI: 10.1155/2020/7038124. View

15.

Cieri-Hutcherson N, Jaenecke A, Bahia A, Lucas D, Oluloro A, Stimmel L . Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy (Basel). 2021; 9(2). PMC: 8103282. DOI: 10.3390/pharmacy9020071. View

16.

Liu W, Zhang L, Gao A, Khawar M, Gao F, Li W . Food-Derived High Arginine Peptides Promote Spermatogenesis Recovery in Busulfan Treated Mice. Front Cell Dev Biol. 2022; 9:791471. PMC: 8724571. DOI: 10.3389/fcell.2021.791471. View

17.

De Luca M, Colone M, Gambioli R, Stringaro A, Unfer V . Oxidative Stress and Male Fertility: Role of Antioxidants and Inositols. Antioxidants (Basel). 2021; 10(8). PMC: 8389261. DOI: 10.3390/antiox10081283. View

18.

Di Guardo F, Vloeberghs V, Bardhi E, Blockeel C, Verheyen G, Tournaye H . Low Testosterone and Semen Parameters in Male Partners of Infertile Couples Undergoing IVF with a Total Sperm Count Greater than 5 Million. J Clin Med. 2020; 9(12). PMC: 7761260. DOI: 10.3390/jcm9123824. View

19.

Fang X, An P, Wang H, Wang X, Shen X, Li X . Dietary intake of heme iron and risk of cardiovascular disease: a dose-response meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis. 2014; 25(1):24-35. DOI: 10.1016/j.numecd.2014.09.002. View

20.

Mahran G, Attia A . A phytochemical study of date palm pollen. Planta Med. 1976; 29(2):171-5. DOI: 10.1055/s-0028-1097648. View