Novel Design and Development of Extract - Loaded Poloxamer/ZnO Nanocomposite Wound Closure Material to Improve Anti-bacterial Action and Enhanced Wound Healing Efficacy in Diabetic Foot Ulcer

Overview

Journal Regen Ther

Date 2024 Mar 27

PMID 38532843

Authors

Lina Wang

Yan Yang

Weiwei Han

Hui Ding

Affiliations

Soon will be listed here.

Abstract

Diabetic wounds can occur as a prevalent complication among people diagnosed with diabetes, frequently resulting in the necessity for amputation. The cause and effect of diabetic foot ulcer is complex, involving multiple factors. In the present study, wound healing strategies utilizing nanomaterials have proven to be effective in battling bacterial infections and improve wound regeneration. Poloxamers (PLX) exhibit extensive potential as a viable option for the development of nanomedicines owing to their inherent characteristics of self-assembly and encapsulation. This study aims to design and develop a PLX/ZnO nanocomposite incorporated with extract (CAE) for the multi-functional action in the diabetic wound healing treatment. Subsequently physico-chemical characterizations, such as XRD, FTIR, and TEM observations, demonstrated that the ZnO were evenly distributed through the PLX framework. The developed nanocomposite was biocompatible with mouse fibroblast cell line (L929), and it had multiple beneficial characteristics, such as a rapid self-healing process and effective antibacterial action against G and G bacterial pathogens. After being treated with the developed formulation, skin fibroblast cell line and HUVECs demonstrated a substantial increase in their cell proliferation ability, migration, and tube-forming abilities. The utilization of a CAE@PLX/ZnO nanoformulation presents a viable strategy and a distinctive, encouraging composite for diabetic wound healing treatment.

Citing Articles

Exploration of the Topical Nanoemulgel Bearing with Ferulic Acid and Essential Oil for Diabetic Wound Healing.

Anuradha U, Bhavana V, Sandeep Chary P, Kalia N, Mehra N Pathophysiology. 2024; 31(4):680-698.

PMID: 39728684 PMC: 11678672. DOI: 10.3390/pathophysiology31040049.

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