Unveiling the Cancer Risk Nexus of the Steatotic Liver

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2024 Mar 26

PMID 38531699

Authors

Jieun Kim

Ekihiro Seki

Affiliations

Soon will be listed here.

Abstract

Steatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses that enhance liver metastasis from extrahepatic primary cancers. This review explores the impact of steatotic liver on hepatic carcinogenesis and metastasis from extrahepatic cancers, with a specific focus on hepatocyte-derived factors and the immune microenvironment. By emphasizing novel conclusions, this article underscores the timely relevance of understanding these intricate connections.

Citing Articles

Inflammation and Immunity in Liver Neoplasms: Implications for Future Therapeutic Strategies.

Kim J, Seki E Mol Cancer Ther. 2024; 24(2):188-199.

PMID: 39365846 PMC: 11794036. DOI: 10.1158/1535-7163.MCT-23-0726.

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