We Have a Community Problem

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Mar 26

PMID 38529952

Authors

George A OToole

Affiliations

Soon will be listed here.

Citing Articles

A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean.

Coolahan M, Whalen K Commun Biol. 2025; 8(1):179.

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High-throughput analysis of microbiomes in a meat processing facility: are food processing facilities an establishment niche for persisting bacterial communities?.

Xu Z, Pham V, Yang X, Ganzle M Microbiome. 2025; 13(1):25.

PMID: 39871374 PMC: 11773833. DOI: 10.1186/s40168-024-02026-1.

Bacterial interactions underpin worsening lung function in cystic fibrosis-associated infections.

Rivett D, Hatfield L, Gavillet H, Hardman M, van der Gast C mBio. 2024; 16(1):e0145624.

PMID: 39576107 PMC: 11708055. DOI: 10.1128/mbio.01456-24.

Characterizing a stable five-species microbial community for use in experimental evolution and ecology.

Castledine M, Pennycook J, Newbury A, Lear L, Erdos Z, Lewis R Microbiology (Reading). 2024; 170(9).

PMID: 39297874 PMC: 11412253. DOI: 10.1099/mic.0.001489.

Metabolic interdependencies in thermophilic communities are revealed using co-occurrence and complementarity networks.

Peng X, Wang S, Wang M, Feng K, He Q, Yang X Nat Commun. 2024; 15(1):8166.

PMID: 39289365 PMC: 11408653. DOI: 10.1038/s41467-024-52532-x.

References

OToole G . Cystic Fibrosis Airway Microbiome: Overturning the Old, Opening the Way for the New. J Bacteriol. 2017; 200(4). PMC: 5786703. DOI: 10.1128/JB.00561-17. View

Hampton T, Thomas D, van der Gast C, OToole G, Stanton B . Mild Cystic Fibrosis Lung Disease Is Associated with Bacterial Community Stability. Microbiol Spectr. 2021; 9(1):e0002921. PMC: 8549546. DOI: 10.1128/Spectrum.00029-21. View

OToole G, Crabbe A, Kummerli R, LiPuma J, Bomberger J, Davies J . Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions. mBio. 2021; 12(5):e0176321. PMC: 8546538. DOI: 10.1128/mBio.01763-21. View

Ross L, Woodward J . Koch's postulates: An interventionist perspective. Stud Hist Philos Biol Biomed Sci. 2016; 59:35-46. DOI: 10.1016/j.shpsc.2016.06.001. View

Baty J, Stoner S, McDaniel M, Huffines J, Edmonds S, Evans N . An oral commensal attenuates -induced airway inflammation and modulates nitrite flux in respiratory epithelium. Microbiol Spectr. 2023; 11(6):e0219823. PMC: 10715204. DOI: 10.1128/spectrum.02198-23. View

Vandeplassche E, Tavernier S, Coenye T, Crabbe A . Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens. Eur Respir Rev. 2019; 28(152). PMC: 9488708. DOI: 10.1183/16000617.0041-2019. View

OBrien S, Fothergill J . The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung. FEMS Microbiol Lett. 2017; 364(15). PMC: 5812498. DOI: 10.1093/femsle/fnx128. View

OBrien T, Welch M . A Continuous-Flow Model for Cultivation of Mixed Microbial Populations Associated With Cystic Fibrosis Airway Infections. Front Microbiol. 2019; 10:2713. PMC: 6883238. DOI: 10.3389/fmicb.2019.02713. View

Jean-Pierre F, Vyas A, Hampton T, Henson M, OToole G . One versus Many: Polymicrobial Communities and the Cystic Fibrosis Airway. mBio. 2021; 12(2). PMC: 8092191. DOI: 10.1128/mBio.00006-21. View

10.

Welch J, Rossetti B, Rieken C, Dewhirst F, Borisy G . Biogeography of a human oral microbiome at the micron scale. Proc Natl Acad Sci U S A. 2016; 113(6):E791-800. PMC: 4760785. DOI: 10.1073/pnas.1522149113. View

11.

Orazi G, Jean-Pierre F, OToole G . Pseudomonas aeruginosa PA14 Enhances the Efficacy of Norfloxacin against Staphylococcus aureus Newman Biofilms. J Bacteriol. 2020; 202(18). PMC: 7925081. DOI: 10.1128/JB.00159-20. View

12.

Kolenbrander P, London J . Adhere today, here tomorrow: oral bacterial adherence. J Bacteriol. 1993; 175(11):3247-52. PMC: 204720. DOI: 10.1128/jb.175.11.3247-3252.1993. View

13.

Jean-Pierre F, Hampton T, Schultz D, Hogan D, Groleau M, Deziel E . Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system. Elife. 2023; 12. PMC: 9897730. DOI: 10.7554/eLife.81604. View

14.

Li K, Gifford A, Hampton T, OToole G . Availability of Zinc Impacts Interactions between Streptococcus sanguinis and Pseudomonas aeruginosa in Coculture. J Bacteriol. 2019; 202(2). PMC: 6941532. DOI: 10.1128/JB.00618-19. View

15.

Lewin G, Stocke K, Lamont R, Whiteley M . A quantitative framework reveals traditional laboratory growth is a highly accurate model of human oral infection. Proc Natl Acad Sci U S A. 2022; 119(2). PMC: 8764681. DOI: 10.1073/pnas.2116637119. View

16.

Baty J, Huffines J, Stoner S, Scoffield J . A Commensal Streptococcus Dysregulates the Nitrosative Stress Response. Front Cell Infect Microbiol. 2022; 12:817336. PMC: 9127344. DOI: 10.3389/fcimb.2022.817336. View

17.

Price K, Naimie A, Griffin E, Bay C, OToole G . Tobramycin-Treated Pseudomonas aeruginosa PA14 Enhances Streptococcus constellatus 7155 Biofilm Formation in a Cystic Fibrosis Model System. J Bacteriol. 2015; 198(2):237-47. PMC: 4751783. DOI: 10.1128/JB.00705-15. View

18.

Orazi G, OToole G . Alters Staphylococcus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection. mBio. 2017; 8(4). PMC: 5516255. DOI: 10.1128/mBio.00873-17. View

19.

Ghosh A, Saha S . Meta-analysis of sputum microbiome studies identifies airway disease-specific taxonomic and functional signatures. J Med Microbiol. 2023; 72(12). DOI: 10.1099/jmm.0.001617. View

20.

Hogan D, Kolter R . Pseudomonas-Candida interactions: an ecological role for virulence factors. Science. 2002; 296(5576):2229-32. DOI: 10.1126/science.1070784. View