Sirtuin 1 Serum Concentration in Healthy Children - Dependence on Sex, Age, Stage of Puberty, Body Weight and Diet

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2024 Mar 26

PMID 38529393

Authors

Anna Fedorczak

Andrzej Lewinski

Renata Stawerska

Affiliations

Soon will be listed here.

Abstract

Introduction: Sirtuin 1 (SIRT1) is known to be involved in sensing cellular energy levels and regulating energy metabolism. This study aimed to evaluate fasting serum SIRT1 levels in healthy children, and to analyse the influence of age, sex, puberty, body weight, height, and diet on its concentration.

Methods: 47 healthy children aged 4-14 with weight and height within normal range and no chronic disease were included into the study. Fasting serum SIRT1 concentrations were estimated by Enzyme Linked Immunosorbent Assay (ELISA).

Results: Results showed that serum SIRT1 concentrations in healthy children did not differ with respect to sex, age, height, weight and puberty. Whereas, it appeared that a higher frequency of fruits, vegetables and dairy products consumption was associated with an increase in serum SIRT1 levels.

Discussion: Studying SIRT1 in the context of children's health may have implications for a broader understanding of growth processes, pubertal development, metabolic disorders and nutrition.

Citing Articles

Relationship between Serum Sirtuin 1 and Growth Hormone/Insulin-like Growth Factor 1 Concentrations in Children with Growth Hormone Deficiency and Idiopathic Short Stature.

Fedorczak A, Kowalik D, Kopciuch J, Glowacka E, Mikolajczyk K, Tkaczyk M Biomedicines. 2024; 12(7).

PMID: 39062007 PMC: 11274889. DOI: 10.3390/biomedicines12071433.

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