Molecular Regulatory Mechanism of Nano-Se Against Copper-Induced Spermatogenesis Disorder

Overview

Journal Biol Trace Elem Res

Date 2024 Mar 26

PMID 38528285

Authors

Yujuan Ouyang

Yanbing Lou

Yanqiu Zhu

Yihan Wang

Song Zhu

Lin Jing

Tingting Yang

Hengmin Cui

Huidan Deng

Zhicai Zuo

Jing Fang

Hongrui Guo

Affiliations

Soon will be listed here.

Abstract

Selenium nanoparticle (Nano-Se) is a new type of selenium supplement, which can improve the deficiency of traditional selenium supplements and maintain its physiological activity. Due to industrial pollution and irrational use in agriculture, Cu overexposure often occurs in animals and humans. In this study, Nano-Se alleviated CuSO-induced testicular Cu accumulation, serum testosterone level decrease, testicular structural damage, and decrease in sperm quality. Meanwhile, Nano-Se reduced the ROS content in mice testis and enhanced the activities of T-AOC, GSH, SOD, and CAT compared with CuSO group. Furthermore, Nano-Se alleviated CuSO-induced apoptosis by increasing the protein expression of Cleaved-Caspase-3, Cleaved-Caspase-9, Cleaved-Caspase-12, and Bax/Bcl-2 compared with CuSO group. At the same time, Nano-Se reversed CuSO-induced increase of γ-H2AX protein expression in mice testis. In conclusion, this study confirmed that Nano-Se could alleviate oxidative stress, apoptosis, and DNA damage in the testis of mice with Cu excess, thereby protecting the spermatogenesis disorder induced by Cu.

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