Circulating Total 25(OH)D and Calculated Free 25(OH)D in Professional Academy Footballers at a Northerly Latitude in the UK

Overview

Journal Biol Sport

Specialty Orthopedics

Date 2024 Mar 25

PMID 38524830

Authors

Simon D Bowles

Subhashis Basu

Mayur K Ranchordas

Trevor Simper

Anthony Lynn

Affiliations

Soon will be listed here.

Abstract

There is limited data on the vitamin D status of UK-based professional academy footballers. Therefore, the objective of this study was to report total 25(OH)D, free 25(OH)D and free 1, 25(OH)D at the end of the winter (March) and summer periods (October) in a cohort (n = 27) of professional academy footballers in northern England. Blood samples were collected to measure total 25(OH)D, parathyroid hormone, vitamin D binding protein, albumin and calcium. Free 25(OH)D and 1, 25(OH)D were calculated. Dietary vitamin D intake and retrospective summer sunlight exposure were also collected. At the end of winter, 2/27 (7.4%) players were vitamin D deficient (25(OH)D < 30 nmol/l) and 11/27 (40.7%) were insufficient (25(OH)D > 30 nmol/l < 50 nmol/l). By the end of summer, none were deficient but 3/14 (21.4%) were still insufficient. Median total 25(OH)D (82.2 nmol/l [IQR: 50.3-90.2] vs. 54.2 nmol/l [IQR: 36.8-71.9]; P = .02), free 25(OH)D (25.8 pmol/l [IQR: 15.1-33.1] vs. 13.2 pmol/l [IQR: 9.0-14.9]; P = .005) and free 1, 25(OH)D (389 fmol/l [IQR: 209-594] vs. 212 fmol/l [IQR: 108-278]; P = .034) were significantly higher at the end of summer than the end of winter. At the end of winter, free 25(OH)D was lower (P = .003) in those vitamin D insufficient (8.8 pmol/l [IQR: 5.5-11.8]) vs. sufficient (13.7 pmol/l [IQR: 12.0-17.0]). There was a high prevalence of vitamin D insufficiency at the end of the winter. Free 25(OH)D was also lower at the winter timepoint and in players that were insufficient vs. sufficient.

Citing Articles

Vitamin D Deficiency in Professional Football Players during Competitive Season of Italian First Division (Serie A).

Perrone M, Pieri M, Caminiti G, Ali W, Bernardini S, Parisi A Sports (Basel). 2024; 12(6).

PMID: 38921847 PMC: 11209379. DOI: 10.3390/sports12060153.

References

Webb A . Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006; 92(1):17-25. DOI: 10.1016/j.pbiomolbio.2006.02.004. View

Smith L, Gallagher J . Effect of vitamin D supplementation on total and free 25 hydroxyvitamin D and parathyroid hormone. An analysis of two randomized controlled trials. J Intern Med. 2019; 286(6):651-659. PMC: 6851404. DOI: 10.1111/joim.12950. View

Morton J, Iqbal Z, Drust B, Burgess D, Close G, Brukner P . Seasonal variation in vitamin D status in professional soccer players of the English Premier League. Appl Physiol Nutr Metab. 2012; 37(4):798-802. DOI: 10.1139/h2012-037. View

He C, Handzlik M, Fraser W, Muhamad A, Preston H, Richardson A . Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes. Exerc Immunol Rev. 2013; 19:86-101. View

Galan F, Ribas J, Sanchez-Martinez P, Calero T, Sanchez A, Munoz A . Serum 25-hydroxyvitamin D in early autumn to ensure vitamin D sufficiency in mid-winter in professional football players. Clin Nutr. 2011; 31(1):132-6. DOI: 10.1016/j.clnu.2011.07.008. View

Bhan I, Powe C, Berg A, Ankers E, Wenger J, Karumanchi S . Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int. 2012; 82(1):84-9. PMC: 3376220. DOI: 10.1038/ki.2012.19. View

Specker B, Tsang R, Ho M, Buckley D . Seasonal differences in serum vitamin D binding protein in exclusively breast-fed infants: negative relationship to sunshine exposure and 25-hydroxyvitamin D. J Pediatr Gastroenterol Nutr. 1986; 5(2):290-4. View

Henry H . Regulation of vitamin D metabolism. Best Pract Res Clin Endocrinol Metab. 2011; 25(4):531-41. DOI: 10.1016/j.beem.2011.05.003. View

Kopec A, Solarz K, Majda F, Slowinska-Lisowska M, Medras M . An evaluation of the levels of vitamin d and bone turnover markers after the summer and winter periods in polish professional soccer players. J Hum Kinet. 2013; 38:135-40. PMC: 3827761. DOI: 10.2478/hukin-2013-0053. View

10.

Bikle D, Schwartz J . Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2019; 10:317. PMC: 6546814. DOI: 10.3389/fendo.2019.00317. View

11.

Shieh A, Chun R, Ma C, Witzel S, Meyer B, Rafison B . Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance. J Clin Endocrinol Metab. 2016; 101(8):3070-8. PMC: 4971338. DOI: 10.1210/jc.2016-1871. View

12.

Skalska M, Nikolaidis P, Knechtle B, Rosemann T, Radziminski L, Jastrzebska J . Vitamin D Supplementation and Physical Activity of Young Soccer Players during High-Intensity Training. Nutrients. 2019; 11(2). PMC: 6412881. DOI: 10.3390/nu11020349. View

13.

Schwartz J, Gallagher J, Jorde R, Berg V, Walsh J, Eastell R . Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab. 2018; 103(9):3278-3288. PMC: 6126881. DOI: 10.1210/jc.2018-00295. View

14.

Close G, Russell J, Cobley J, Owens D, Wilson G, Gregson W . Assessment of vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function. J Sports Sci. 2012; 31(4):344-53. DOI: 10.1080/02640414.2012.733822. View

15.

Ksiazek A, Zagrodna A, Slowinska-Lisowska M . Vitamin D, Skeletal Muscle Function and Athletic Performance in Athletes-A Narrative Review. Nutrients. 2019; 11(8). PMC: 6722905. DOI: 10.3390/nu11081800. View

16.

Brzezianski M, Migdalska-Sek M, Czechowska A, Radziminski L, Jastrzebski Z, Brzezianska-Lasota E . Correlation between the Positive Effect of Vitamin D Supplementation and Physical Performance in Young Male Soccer Players. Int J Environ Res Public Health. 2022; 19(9). PMC: 9101676. DOI: 10.3390/ijerph19095138. View

17.

Ross A, Manson J, Abrams S, Aloia J, Brannon P, Clinton S . The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2010; 96(1):53-8. PMC: 3046611. DOI: 10.1210/jc.2010-2704. View

18.

Powe C, Ricciardi C, Berg A, Erdenesanaa D, Collerone G, Ankers E . Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011; 26(7):1609-16. PMC: 3351032. DOI: 10.1002/jbmr.387. View

19.

Koundourakis N, Androulakis N, Malliaraki N, Margioris A . Vitamin D and exercise performance in professional soccer players. PLoS One. 2014; 9(7):e101659. PMC: 4081585. DOI: 10.1371/journal.pone.0101659. View

20.

Malmstroem S, Rejnmark L, Imboden J, Shoback D, Bikle D . Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. J AOAC Int. 2017; 100(5):1323-1327. DOI: 10.5740/jaoacint.17-0085. View