Elucidating Cyathula Officinals' Mechanism in Osteoarthritis Treatment: Network Pharmacology and Empirical Evidence on Anti-inflammatory Actions

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Mar 25

PMID 38524622

Authors

Zhicheng Yao

Fengping Gan

Yuqing Zeng

Litong Ren

Yirong Zeng

Affiliations

Soon will be listed here.

Abstract

In this study, we explored the therapeutic potential of Cyathula Officinals (CNX) in Knee Osteoarthritis (KOA) treatment. Utilizing network pharmacology and in vitro experiments, we identified active ingredients, action targets and pathways in CNX. Our analysis, integrating databases like TCMSP, SwissTarget Prediction, Genecards, CTD, STRING, and DAVID, highlighted 396 action targets and 283 disease targets, pinpointing 64 intersection genes linked to KOA. The significant involvement of the MAPK and NF-κB pathways in CNX's anti-inflammatory action was validated through qPCR, which might underlie CNX's efficacy in inhibiting chondrocyte apoptosis and IL-6 expression. These findings suggest CNX's potential in KOA management, offering insights for its clinical application.

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