Recent Research Advances in Pain Mechanisms in McCune-Albright Syndrome Thinking About the Pain Mechanism of FD/MAS

Overview

Journal J Orthop Surg Res

Publisher Biomed Central

Specialty Orthopedics

Date 2024 Mar 22

PMID 38515135

Authors

Yong Wang

Tao Jiang

Affiliations

Soon will be listed here.

Abstract

Background: The lack of effective understanding of the pain mechanism of McCune-Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma.

Objective: This paper summarizes the novel mechanisms, targets, and treatments that may produce pain in MAS and fibrous dysplasia (polyfibrous dysplasia, or FD).

Methods: We conducted a systematic search in the PubMed database, Web of Science, China Knowledge Network (CNKI) with the following keywords: "McCune-Albright syndrome (MAS); polyfibrous dysplasia (FD); bone pain; bone remodeling; G protein coupled receptors; GDNF family receptors; purinergic receptors and glycogen synthase kinase", as well as other keywords were systematically searched. Papers published between January 2018 and May 2023 were selected for finding. Initial screening was performed by reading the titles and abstracts, and available literature was screened against the inclusion and exclusion criteria.

Results: In this review, we systematically analyzed the cutting-edge advances in this disease, synthesized the findings, and discussed the differences. With regard to the complete mechanistic understanding of the pain condition in FD/MAS, in particular, we collated new findings on new pathways, neurotrophic factor receptors, purinergic receptors, interferon-stimulating factors, potassium channels, protein kinases, and corresponding hormonal modulation and their respective strengths and weaknesses.

Conclusion: This paper focuses on basic research to explore FD/MAS pain mechanisms. New nonneuronal and molecular mechanisms, mechanically loaded responsive neurons, and new targets for potential clinical interventions are future research directions, and a large number of animal experiments, tissue engineering techniques, and clinical trials are still needed to verify the effectiveness of the targets in the future.

References

Taguchi T, Mukai K, Takaya E, Shindo R . STING Operation at the ER/Golgi Interface. Front Immunol. 2021; 12:646304. PMC: 8126659. DOI: 10.3389/fimmu.2021.646304. View

Duitama M, Vargas-Lopez V, Casas Z, Albarracin S, Sutachan J, Torres Y . TRP Channels Role in Pain Associated With Neurodegenerative Diseases. Front Neurosci. 2020; 14:782. PMC: 7417429. DOI: 10.3389/fnins.2020.00782. View

Scarpellino G, Genova T, Quarta E, Distasi C, Dionisi M, Fiorio Pla A . P2X Purinergic Receptors Are Multisensory Detectors for Micro-Environmental Stimuli That Control Migration of Tumoral Endothelium. Cancers (Basel). 2022; 14(11). PMC: 9179260. DOI: 10.3390/cancers14112743. View

Nencini S, Ringuet M, Kim D, Greenhill C, Ivanusic J . GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain. J Neurosci. 2018; 38(21):4899-4911. PMC: 6596122. DOI: 10.1523/JNEUROSCI.0421-18.2018. View

Perin M, Chinigo G, Genova T, Mussano F, Munaron L . The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis. Antioxidants (Basel). 2023; 12(3). PMC: 10045377. DOI: 10.3390/antiox12030689. View

Yuan Z, Liu X, Zhang Z, Li S, Tian Y, Xi K . Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain. iScience. 2022; 25(9):104936. PMC: 9441333. DOI: 10.1016/j.isci.2022.104936. View

Du L, Feng R, Ge S . PTH/SDF-1α cotherapy promotes proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells. Cell Prolif. 2016; 49(5):599-608. PMC: 6496697. DOI: 10.1111/cpr.12286. View

Corrigan M, Johnson G, Stavenschi E, Riffault M, Labour M, Hoey D . TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium. Sci Rep. 2018; 8(1):3824. PMC: 5830574. DOI: 10.1038/s41598-018-22174-3. View

Chen W, Li H, Hao X, Liu C . TRPV1 in dorsal root ganglion contributed to bone cancer pain. Front Pain Res (Lausanne). 2022; 3:1022022. PMC: 9682177. DOI: 10.3389/fpain.2022.1022022. View

10.

Minnema L, Gupta A, Mishra S, Lascelles B . Investigating the Role of Artemin and Its Cognate Receptor, GFRα3, in Osteoarthritis Pain. Front Neurosci. 2022; 16:738976. PMC: 8829392. DOI: 10.3389/fnins.2022.738976. View

11.

Wang L, You X, Lotinun S, Zhang L, Wu N, Zou W . Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nat Commun. 2020; 11(1):282. PMC: 6962448. DOI: 10.1038/s41467-019-14146-6. View

12.

Turner T, Sharma K, Oh E, Liu Y, Collins R, Sosa M . Loss of δ-catenin function in severe autism. Nature. 2015; 520(7545):51-6. PMC: 4383723. DOI: 10.1038/nature14186. View

13.

Decout A, Katz J, Venkatraman S, Ablasser A . The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol. 2021; 21(9):548-569. PMC: 8029610. DOI: 10.1038/s41577-021-00524-z. View

14.

Tamma R, Colaianni G, Zhu L, DiBenedetto A, Greco G, Montemurro G . Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U S A. 2009; 106(17):7149-54. PMC: 2678458. DOI: 10.1073/pnas.0901890106. View

15.

Liu M, Cheng X, Yan H, Chen J, Liu C, Chen Z . MiR-135-5p Alleviates Bone Cancer Pain by Regulating Astrocyte-Mediated Neuroinflammation in Spinal Cord through JAK2/STAT3 Signaling Pathway. Mol Neurobiol. 2021; 58(10):4802-4815. DOI: 10.1007/s12035-021-02458-y. View

16.

Gupta A, Chiavaccini L, Minnema L, Chiu K, Knazovicky D, Hash J . Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain. Sci Rep. 2021; 11(1):6682. PMC: 7988108. DOI: 10.1038/s41598-021-85976-y. View

17.

Guerrero-Solano J, Bautista M, Velazquez-Gonzalez C, de la O-Arciniega M, Gonzalez-Olivares L, Fernandez-Moya M . Antinociceptive Synergism of Pomegranate Peel Extract and Acetylsalicylic Acid in an Animal Pain Model. Molecules. 2021; 26(18). PMC: 8469324. DOI: 10.3390/molecules26185434. View

18.

Lawson K . Identification of the Involvement of Potassium Channels in Fibromyalgia. Front Biosci (Schol Ed). 2022; 14(4):29. DOI: 10.31083/j.fbs1404029. View

19.

Koivisto A, Belvisi M, Gaudet R, Szallasi A . Advances in TRP channel drug discovery: from target validation to clinical studies. Nat Rev Drug Discov. 2021; 21(1):41-59. PMC: 8442523. DOI: 10.1038/s41573-021-00268-4. View

20.

Guedon J, Longo G, Majuta L, Thomspon M, Fealk M, Mantyh P . Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain. Pain. 2016; 157(6):1239-1247. PMC: 5142607. DOI: 10.1097/j.pain.0000000000000514. View