Alterations in Articular Cartilage Frictional Properties in the Setting of Acute Gouty Arthritis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Mar 21

PMID 38512881

Authors

Pai Zheng

Xueer Zhang

Chengcheng Feng

Yuhong Yu

Guangwei Che

Zhihong Cao

Li Tian

Yong Huang

Affiliations

Soon will be listed here.

Abstract

The tribological behaviour of articular cartilage plays a key role in joint motion; however, there is a gap in research on the effect of hyperuricemic joint fluid on cartilage friction behaviour in acute gouty arthritis. In this study, we carried out a fixed-load scratch experiment to compare the friction and wear of articular cartilage under the lubrication of gouty arthritis arthritic fluid and normal human arthritic fluid, and the results showed that the cartilage friction coefficient of patients with acute gouty arthritis was significantly larger than that of normal human beings, and that the cartilage friction coefficient decreased with the elevation of normal load and sliding speed, and the change with the sliding speed varied more differently from that of normal human beings, and that the cartilage surface wear was more severe after prolonged friction. The wear and tear of the cartilage surface is more severe after prolonged friction. Patients with gouty arthritis should reduce the sudden speed changes such as fast running and variable speed running to maintain the stability of the cartilage surface friction coefficient.

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