Comparison of CT Acquired Cardiac Valvular Calcification Scores in Hemodialysis and Peritoneal Dialysis Patients Undergoing Open Heart Surgery

Overview

Journal Am Heart J Plus

Specialty Cardiology & Vascular Diseases

Date 2024 Mar 21

PMID 38510498

Authors

Christopher N Kanaan

Habib Layoun

Nicholas P Kondoleon

Remy Fadel

Saeid Mirzai

Jesse Schold

Susana Arrigain

Remy Daou

Ali Mehdi

Jonathan J Taliercio

Shinya Unai

Samir Kapadia

Serge Harb

Georges N Nakhoul

Affiliations

Soon will be listed here.

Abstract

Study Objective: Data is scarce regarding which dialysis modality portends more severe cardiac valvular calcification (CVC). Our aim was to compare the degree of CVC in hemodialysis (HD) and peritoneal dialysis (PD) patient cohorts prior to open heart surgery (OHS) using a CT calcium score.

Design Setting And Participants: Dialysis patients who underwent OHS at our institution from 2009 to 2019 and who had pre-surgical cardiac CT were included in our study. We obtained duration of dialysis modality prior to their surgical date. There were two study cohorts to evaluate outcomes of interest: mitral and aortic calcification. CVC was assessed using the Agatston score. Logistic regression was performed to test for the association of PD and HD cumulative dialysis duration with presence of CVC.

Results: A total of 214 and 166 patients met inclusion for the mitral and aortic strata, respectively. Age, female sex, and BMI were associated with higher odds of presence of mitral calcification. Age and BMI were associated with higher odds of presence of aortic calcification, while female sex was associated with lower odds in the aortic strata. Cumulative years on PD and cumulative years on HD were not significantly associated with presence of CVC in either cohort.

Conclusion: Presence of mitral and aortic calcification for patients undergoing OHS was not significantly associated with cumulative length of PD or HD after adjusting for age, gender, and BMI suggesting that there may be more factors at play in the progression of CVC in end stage renal disease patients than what was previously established.

Citing Articles

Gla-Rich Protein Is Associated with Vascular Calcification, Inflammation, and Mineral Markers in Peritoneal Dialysis Patients.

Marreiros C, Viegas C, Guedes A, Paula Silva A, Aguas A, Faisca M J Clin Med. 2024; 13(23).

PMID: 39685887 PMC: 11642258. DOI: 10.3390/jcm13237429.

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