Comparison of Mortality and Outcomes of Four Respiratory Viruses in the Intensive Care Unit: a Multicenter Retrospective Study

Overview

Journal Sci Rep

Specialty Science

Date 2024 Mar 21

PMID 38509095

Authors

Baptiste Grangier

Charles-Herve Vacheron

Donatien De Marignan

Jean-Sebastien Casalegno

Sandrine Couray-Targe

Audrey Bestion

Florence Ader

Jean-Christophe Richard

Emilie Frobert

Laurent Argaud

Thomas Rimmele

Anne-Claire Lukaszewicz

Frederic Aubrun

Frederic Dailler

Jean-Luc Fellahi

Julien Bohe

Vincent Piriou

Bernard Allaouchiche

Arnaud Friggeri

Florent Wallet

Affiliations

Soon will be listed here.

Abstract

This retrospective study aimed to compare the mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities than the other patients. At admission, patients in the COVID-19 group were significantly less severe than the others according to the simplified acute physiology score-2 (SAPS-II) and sepsis-related organ failure assessment (SOFA) scores. Using competing risk regression, COVID-19 (sHR = 1.61; 95% CI 1.10; 2.36) and H1N1 (sHR = 1.87; 95% CI 1.20; 2.93) were associated with a statistically significant higher mortality while seasonal influenza was not (sHR = 0.93; 95% CI 0.65; 1.31), when compared to RSV. Despite occurring in more severe patients, RSV and seasonal influenza group appear to be associated with a more favorable outcome than COVID-19 and H1N1 groups.

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