» Articles » PMID: 38500081

Management of Kidney Transplant Recipients for Primary Care Practitioners

Overview
Journal BMC Nephrol
Publisher Biomed Central
Specialty Nephrology
Date 2024 Mar 19
PMID 38500081
Authors
Affiliations
Soon will be listed here.
Abstract

Patients with kidney transplants have a significant co-morbidity index, due to a high number of pre-existing conditions and use of immunosuppression medications. These patients are at higher risk of developing conditions such as hypertension, dyslipidemia, post-transplant diabetes, cardiovascular events, and anemia. Moreover, they are particularly susceptible to infections such as urinary tract infections or pyelonephritis, cancers, and gastrointestinal complications such as diarrhea, which in turn may be attributed to medication adverse effects or infectious causes. Along with these concerns, meticulous management of electrolytes and allograft function is essential. Prior to prescribing any new medications, it is imperative to exercise caution in identifying potential interactions with immunosuppression drugs. This review aims to equip primary care practitioners to address these complex issues and appropriate methods of delivering care to this rapidly growing highly susceptible group.

References
1.
Farouk S, Rein J . The Many Faces of Calcineurin Inhibitor Toxicity-What the FK?. Adv Chronic Kidney Dis. 2020; 27(1):56-66. PMC: 7080294. DOI: 10.1053/j.ackd.2019.08.006. View

2.
BEHREND M . Adverse gastrointestinal effects of mycophenolate mofetil: aetiology, incidence and management. Drug Saf. 2001; 24(9):645-63. DOI: 10.2165/00002018-200124090-00002. View

3.
Nelson J, Alvey N, Bowman L, Schulte J, Segovia M, McDermott J . Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and the International Society for Heart and Lung.... Pharmacotherapy. 2022; 42(8):599-633. DOI: 10.1002/phar.2716. View

4.
Bunnapradist S, Neri L, Wong W, Lentine K, Burroughs T, Pinsky B . Incidence and risk factors for diarrhea following kidney transplantation and association with graft loss and mortality. Am J Kidney Dis. 2008; 51(3):478-86. DOI: 10.1053/j.ajkd.2007.11.013. View

5.
Goldman J, Julian K . Urinary tract infections in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019; 33(9):e13507. DOI: 10.1111/ctr.13507. View