Brain-derived Endothelial Cells Are Neuroprotective in a Chronic Cerebral Hypoperfusion Mouse Model

Overview

Journal Commun Biol

Specialty Biology

Date 2024 Mar 19

PMID 38499610

Authors

Yuichi Matsui

Fumitaka Muramatsu

Hajime Nakamura

Yoshimi Noda

Kinnosuke Matsumoto

Haruhiko Kishima

Nobuyuki Takakura

Affiliations

Soon will be listed here.

Abstract

Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an important target for treating chronic cerebral hypoperfusion. Brain-derived ECs transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential. They were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors. The in vitro coculture of brain cells with ECs from several diverse organs suggested the function of brain-derived endothelium is affected within a brain environment due to netrin-1 and Unc 5B systems. We found brain CD157-positive ECs were more proliferative and beneficial in a mouse model of chronic cerebral hypoperfusion than CD157-negative ECs upon inoculation. We propose novel methods to improve the symptoms of chronic cerebral hypoperfusion using CD157-positive ECs.

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