What else Should Hemostatic Materials Do Beyond Hemostasis: A Review

Overview

Journal Mater Today Bio

Specialty Biomedical Engineering

Date 2024 Mar 18

PMID 38495915

Authors

Xinran Yang

Xiudan Wang

Xing Gao

Xiaoqin Guo

Shike Hou

Jie Shi

Qi Lv

Affiliations

Soon will be listed here.

Abstract

Massive blood loss due to injury is the leading cause of prehospital deaths in disasters and emergencies. Hemostatic materials are used to realize rapid hemostasis and protect patients from death. Researchers have designed and developed a variety of hemostatic materials. However, in addition to their hemostatic effect, hemostatic materials must be endowed with additional functions to meet the practical application requirements in different scenarios. Here, strategies for modifications of hemostatic materials for use in different application scenarios are listed: effective positioning at the site of deep and narrow wounds to stop bleeding, resistance to high blood pressure and wound movement to maintain wound formation, rapid and easy removal from the wound without affecting further treatment after hemostasis is completed, and continued function when retained in the wound as a dressing (such as antibacterial, antiadhesion, tissue repair, etc.). The problems encountered in the practical use of hemostatic materials and the strategies and progress of researchers will be further discussed in this review. We hope to provide valuable references for the design of more comprehensive and practical hemostatic materials.

Citing Articles

Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion.

Yang X, Wang X, Tang L, Sun Z, Gao X, Zhao Y Mater Today Bio. 2025; 30():101431.

PMID: 39830134 PMC: 11742595. DOI: 10.1016/j.mtbio.2024.101431.

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