Identity and Nature of Neural Stem Cells in the Adult Human Subventricular Zone

Overview

Journal iScience

Publisher Cell Press

Date 2024 Mar 18

PMID 38495819

Authors

Salma Baig

Javad Nadaf

Redouane Allache

Phuong U Le

Michael Luo

Annisa Djedid

Andriniaina Nkili-Meyong

Maryam Safisamghabadi

Alex Prat

Jack Antel

Marie-Christine Guiot

Kevin Petrecca

Affiliations

Soon will be listed here.

Abstract

The existence of neural stem cells (NSCs) in adult human brain neurogenic regions remains unresolved. To address this, we created a cell atlas of the adult human subventricular zone (SVZ) derived from fresh neurosurgical samples using single-cell transcriptomics. We discovered 2 adult radial glia (RG)-like populations, aRG1 and aRG2. aRG1 shared features with fetal early RG (eRG) and aRG2 were transcriptomically similar to fetal outer RG (oRG). We also captured early neuronal and oligodendrocytic NSC states. We found that the biological programs driven by their transcriptomes support their roles as early lineage NSCs. Finally, we show that these NSCs have the potential to transition between states and along lineage trajectories. These data reveal that multipotent NSCs reside in the adult human SVZ.

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