Mechanisms and Therapeutic Strategies for Senescence-associated Secretory Phenotype in the Intervertebral Disc Degeneration Microenvironment

Overview

Journal J Orthop Translat

Publisher Elsevier

Specialty Orthopedics

Date 2024 Mar 18

PMID 38495743

Authors

Yang Liu

Yiming Dou

Xun Sun

Qiang Yang

Affiliations

Soon will be listed here.

Abstract

The Translational Potential Of This Article: Existing treatment strategies often fall short in addressing the challenge of repairing intervertebral disc Intervertebral disc degeneration（IVD） degeneration. The accumulation of senescent cells and the continuous release of senescence-associated secretory phenotype (SASP) perpetually impede disc homeostasis and hinder tissue regeneration. This impairment in repair capability presents a significant obstacle to the practical clinical implementation of strategies for intervertebral disc degeneration. As a result, we present a comprehensive overview of the latest advancements in research, the associated regulatory mechanisms, and strategies for treating SASP in IVD cells. This article aims to investigate effective interventions for delaying the onset and progression of age-related intervertebral disc degeneration. In an era where the aging population is becoming increasingly prominent, this endeavor holds paramount practical and translational significance.

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