In Vivo Measurement of the Biomechanical Properties of Human Skin with Motion-corrected Brillouin Microscopy

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2024 Mar 18

PMID 38495685

Authors

Maria N Romodina

Asha Parmar

Kanwarpal Singh

Affiliations

Soon will be listed here.

Abstract

Biomechanical testing of human skin in vivo is important to study the aging process and pathological conditions such as skin cancer. Brillouin microscopy allows the all-optical, non-contact visualization of the mechanical properties of cells and tissues over space. Here, we use the combination of Brillouin microscopy and optical coherence tomography for motion-corrected, depth-resolved biomechanical testing of human skin in vivo. We obtained two peaks in the Brillouin spectra for the epidermis, the first at 7 GHz and the second near 9-10 GHz. The experimentally measured Brillouin frequency shift of the dermis is lower compared to the epidermis and is 6.8 GHz, indicating the lower stiffness of the dermis.

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