The Effects of Poly-GA and Poly-PR Dipeptide Repeats on Sleep Patterns in

Overview

Journal MicroPubl Biol

Specialty Biology

Date 2024 Mar 18

PMID 38495583

Authors

Genevieve Uy

Laura N Farrell

Syeda F Faheem

Lauren E Kinne

Madison G Adore

Seol Hee Im

Robert Fairman

Affiliations

Soon will be listed here.

Abstract

is the most common familial gene associated with amyotrophic lateral sclerosis (ALS). Dipeptide repeats (DPRs) encoded by an expanded nucleotide repeat sequence in the gene were found in the sleep-related neurons of patients, indicating a role of DPRs in ALS-associated sleep disruptions. Poly-GA or poly-PR DPRs were expressed in male to study their effect on sleep Poly-PR expression caused sleep disruptions while poly-GA expression did not. This study validates the use of as an model system for exploring the roles of DPRs in perturbing the underlying molecular mechanisms in sleep regulation.

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