Thoracic Fluid Content (TFC) Using Electrical Cardiometry Versus Lung Ultrasound in the Diagnosis of Transient Tachypnea of Newborn

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2024 Mar 15

PMID 38488876

Authors

Nagwa Mohamed Abd El-Fattah

Heba Saied El-Mahdy

Manal Fathy Hamisa

Ashraf Mohamed Ibrahim

Affiliations

Soon will be listed here.

Abstract

This study aimed to evaluate TFC by EC versus lung ultrasound (LUS) findings for diagnosing and follow-up of TTN in late preterm and term neonates. This prospective observational study was conducted on 80 neonates with gestational age ≥ 34 weeks. TTN group included 40 neonates diagnosed with TTN, and no lung disease (NLD) group included 40 neonates without respiratory distress. LUS and EC were performed within the first 24 h of life and repeated after 72 h. There was a statistically significant increase in TFC in TTN group on D1 [48.48 ± 4.86 (1 KOhm)] compared to NLD group [32.95 ± 4.59 (1 KOhm)], and then significant decrease in TFC in D3 [34.90 ± 4.42 (1 KOhm)] compared to D1 in the TTN group. There was a significant positive correlation between both TFC and LUS with Downes' score, TTN score, and duration of oxygen therapy in the TTN group. Conclusion: Both LUS and TFC by EC provide good bedside tools that could help to diagnose and monitor TTN. TFC showed a good correlation with LUS score and degree of respiratory distress. What is Known: • Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress in newborns. • TTN is a diagnosis of exclusion, there are no specific clinical parameters or biomarker has been identified for TTN. What is New: • Thoracic fluid content (TFC) by electrical cardiometry is a new parameter to evaluate lung fluid volume and could help to diagnose and monitor TTN and correlates with lung ultrasound score.

Citing Articles

Thoracic electrical bioimpedance in preterm newborns with and without respiratory distress syndrome: an exploratory observational study.

Paviotti G, Pavan M, Driutti M, Beorchia Y, Castriotta L, Risso F Eur J Pediatr. 2025; 184(3):208.

PMID: 39992455 DOI: 10.1007/s00431-025-06049-0.

Transient tachypnoea: new concepts on the commonest neonatal respiratory disorder.

Neri C, Sartorius V, De Luca D Eur Respir Rev. 2025; 34(175).

PMID: 39909500 PMC: 11795285. DOI: 10.1183/16000617.0112-2024.

References

Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan R . Recent Advances in Pathophysiology and Management of Transient Tachypnea of Newborn. J Perinatol. 2020; 41(1):6-16. PMC: 11867197. DOI: 10.1038/s41372-020-0757-3. View

Senaldi L, Blatt L, Han J, Gozum G, Venturini S, Hauft S . A quality improvement initiative to reduce antibiotic use in transient tachypnea of the newborn. J Perinatol. 2023; 44(1):119-124. DOI: 10.1038/s41372-023-01850-x. View

Liu J . Lung ultrasonography for the diagnosis of neonatal lung disease. J Matern Fetal Neonatal Med. 2013; 27(8):856-61. DOI: 10.3109/14767058.2013.844125. View

Moresco L, Romantsik O, Calevo M, Bruschettini M . Non-invasive respiratory support for the management of transient tachypnea of the newborn. Cochrane Database Syst Rev. 2020; 4:CD013231. PMC: 7164572. DOI: 10.1002/14651858.CD013231.pub2. View

Liu J, Wang Y, Fu W, Yang C, Huang J . Diagnosis of neonatal transient tachypnea and its differentiation from respiratory distress syndrome using lung ultrasound. Medicine (Baltimore). 2014; 93(27):e197. PMC: 4602774. DOI: 10.1097/MD.0000000000000197. View

Hsu K, Wu T, Wang Y, Lim W, Lee C, Lien R . Hemodynamic reference for neonates of different age and weight: a pilot study with electrical cardiometry. J Perinatol. 2016; 36(6):481-5. DOI: 10.1038/jp.2016.2. View

Noori S, Drabu B, Soleymani S, Seri I . Continuous non-invasive cardiac output measurements in the neonate by electrical velocimetry: a comparison with echocardiography. Arch Dis Child Fetal Neonatal Ed. 2012; 97(5):F340-3. DOI: 10.1136/fetalneonatal-2011-301090. View

Gupta D, Dhingra S . Electrocardiometry Fluid Responsiveness in Pediatric Septic Shock. Indian J Crit Care Med. 2021; 25(2):123-125. PMC: 7922445. DOI: 10.5005/jp-journals-10071-23745. View

Paviotti G, De Cunto A, Moressa V, Bettiol C, Demarini S . Thoracic fluid content by electric bioimpedance correlates with respiratory distress in newborns. J Perinatol. 2017; 37(9):1024-1027. DOI: 10.1038/jp.2017.100. View

10.

Boet A, Jourdain G, Demontoux S, De Luca D . Stroke volume and cardiac output evaluation by electrical cardiometry: accuracy and reference nomograms in hemodynamically stable preterm neonates. J Perinatol. 2016; 36(9):748-52. DOI: 10.1038/jp.2016.65. View

11.

Ballard J, Khoury J, WEDIG K, Wang L, Lipp R . New Ballard Score, expanded to include extremely premature infants. J Pediatr. 1991; 119(3):417-23. DOI: 10.1016/s0022-3476(05)82056-6. View

12.

De Luca D, van Kaam A, Tingay D, Courtney S, Danhaive O, Carnielli V . The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity. Lancet Respir Med. 2017; 5(8):657-666. DOI: 10.1016/S2213-2600(17)30214-X. View

13.

Biasucci D, Loi B, Centorrino R, Raschetti R, Piastra M, Pisapia L . Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study. Respir Res. 2022; 23(1):360. PMC: 9759805. DOI: 10.1186/s12931-022-02294-1. View

14.

Vandenbroucke J, von Elm E, Altman D, Gotzsche P, Mulrow C, Pocock S . Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Ann Intern Med. 2007; 147(8):W163-94. DOI: 10.7326/0003-4819-147-8-200710160-00010-w1. View

15.

Singh Y, Tissot C, Fraga M, Yousef N, Cortes R, Lopez J . International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). Crit Care. 2020; 24(1):65. PMC: 7041196. DOI: 10.1186/s13054-020-2787-9. View

16.

Brat R, Yousef N, Klifa R, Reynaud S, Aguilera S, De Luca D . Lung Ultrasonography Score to Evaluate Oxygenation and Surfactant Need in Neonates Treated With Continuous Positive Airway Pressure. JAMA Pediatr. 2015; 169(8):e151797. DOI: 10.1001/jamapediatrics.2015.1797. View

17.

ONeill R, Dempsey E, Garvey A, Schwarz C . Non-invasive Cardiac Output Monitoring in Neonates. Front Pediatr. 2021; 8:614585. PMC: 7880199. DOI: 10.3389/fped.2020.614585. View

18.

Raimondi F, Yousef N, Rodriguez Fanjul J, De Luca D, Corsini I, Shankar-Aguilera S . A Multicenter Lung Ultrasound Study on Transient Tachypnea of the Neonate. Neonatology. 2019; 115(3):263-268. DOI: 10.1159/000495911. View

19.

Corsini I, Parri N, Ficial B, Dani C . Lung ultrasound in the neonatal intensive care unit: Review of the literature and future perspectives. Pediatr Pulmonol. 2020; 55(7):1550-1562. DOI: 10.1002/ppul.24792. View

20.

Bassiouny M, Abdelhady S, Sobh A . Thoracic Fluid Content in Neonates Presented with Respiratory Distress as a Predictive Tool for Transient Tachypnea of Newborn. Am J Perinatol. 2022; 41(S 01):e109-e113. DOI: 10.1055/s-0042-1750119. View