Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder in Huntington Disease Patient with Improvement in Neuropsychiatric and Movement Symptoms: A Case Report

Overview

Journal Case Rep Neurol

Publisher Karger

Specialty Neurology

Date 2024 Mar 15

PMID 38487476

Authors

Cheyenne Rahn

Kris Peterson

Elizabeth Lamb

Affiliations

Soon will be listed here.

Abstract

Introduction: Huntington disease (HD) is a progressive disorder characterized by significant neurodegeneration that results in severe neuropsychiatric symptoms and disordered movement. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment that has been used in major depressive disorder (MDD) with great success.

Case Presentation: We present a case of a patient with newly diagnosed HD, persistent MDD with suicidal ideation, and generalized anxiety disorder who was treated with rTMS and had sustained significant improvement of her mood disorder with additional improvement of her movement disorder.

Conclusion: This result brings into question the use of rTMS to treat MDD and chorea in patients with HD, especially early in its course.

Citing Articles

Pathomechanisms of behavioral abnormalities in Huntington disease: an update.

Jellinger K J Neural Transm (Vienna). 2024; 131(9):999-1012.

PMID: 38874766 DOI: 10.1007/s00702-024-02794-y.

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