Gastric Inflammatory Myofibroblastic Tumor: a Case Report

Overview

Journal Surg Case Rep

Specialty General Surgery

Date 2024 Mar 15

PMID 38485843

Authors

Taku Hattori

Yutaka Tanizawa

Tadakazu Shimoda

Yusuke Koseki

Kenichiro Furukawa

Keiichi Fujiya

Daisuke Aizawa

Takashi Sugino

Masanori Terashima

Etsuro Bando

Affiliations

Soon will be listed here.

Abstract

Background: Inflammatory myofibroblastic tumor (IMT) of the stomach is an uncommon mesenchymal neoplasm. We present a case of gastric submucosal tumor (SMT) where the final diagnosis was IMT.

Case Presentation: A 69-year-old man presented with a 24-mm SMT on the posterior wall of the middle third of the stomach that was detected by screening upper gastrointestinal endoscopy. Abdominal contrast-enhanced computed tomography showed that the tumor was well-enhanced. Although endoscopic ultrasonography-guided biopsy was performed, the histological diagnosis was not confirmed preoperatively. Since the tumor was clinically suspected to be a gastrointestinal stromal tumor, we performed gastric wedge resection by laparoscopic-endoscopic cooperative surgery. Pathologically, proliferative spindle cells with a positive reaction for smooth muscle actin, negativity for c-kit, desmin, s-100, CD34, STAT-6, β-catenin and anaplastic lymphoma kinase 1 were identified. Hence, the tumor was finally diagnosed as an IMT originating from the stomach.

Conclusions: When an SMT of the stomach is identified, the possibility of gastric IMT should be considered.

Citing Articles

A Diagnosis of Gastric Inflammatory Myofibroblast Tumor: A Challenge Like No Other!.

Chukkalore D, Loeffler J, Rabah H, Amarnath S, Al Moussawi H, Deeb L ACG Case Rep J. 2024; 11(7):e01416.

PMID: 38988714 PMC: 11236408. DOI: 10.14309/crj.0000000000001416.

References

Chong A, Ha J, Hong R, Park S, Lee H . Inflammatory myofibroblastic tumor mimicking gastric gastrointestinal stromal tumor on 18F-FDG PET/CT. Clin Nucl Med. 2014; 39(8):725-7. DOI: 10.1097/RLU.0000000000000392. View

Fan J, Huang B, Yang X, Yang M, He J, Nie X . ALK-positive gastric inflammatory myofibroblastic tumor in an adult with familial adenomatous polyposis and diffuse fundic polyposis. Diagn Pathol. 2017; 12(1):68. PMC: 5604288. DOI: 10.1186/s13000-017-0645-0. View

Hamidah A, Khu S, Thambidorai C, Muhaizan W, Zarina A, Jamal R . Recurrent gastric inflammatory myofibroblastic tumour in a 13-year-old male. Pediatr Surg Int. 2006; 23(6):601-3. DOI: 10.1007/s00383-006-1823-4. View

Morales Prillwitz O, Perez Hurtado B, Olaya Alvarez S, Arevalo Sanchez N, Astudillo Palomino R . Gastric inflammatory myofibroblastic tumor in a 10-month-old girl: A case report. Int J Surg Case Rep. 2020; 68:185-189. PMC: 7068046. DOI: 10.1016/j.ijscr.2020.02.062. View

Lazure T, Ferlicot S, Gauthier F, Doz F, Couturier J, Fabre M . Gastric inflammatory myofibroblastic tumors in children: an unpredictable course. J Pediatr Gastroenterol Nutr. 2002; 34(3):319-22. DOI: 10.1097/00005176-200203000-00020. View

Chen W, Jiang Z, Zhou F, Wu Z, Jiang G, Zhang B . A large inflammatory myofibroblastic tumor involving both stomach and spleen: A case report and review of the literature. Oncol Lett. 2015; 9(2):811-815. PMC: 4301536. DOI: 10.3892/ol.2014.2761. View

Greenson J . Gastrointestinal stromal tumors and other mesenchymal lesions of the gut. Mod Pathol. 2003; 16(4):366-75. DOI: 10.1097/01.MP.0000062860.60390.C7. View

Kim D, Kim W . Inflammatory myofibroblastic tumor treated with laparoscopic proximal gastrectomy and double-tract anastomosis. J Gastric Cancer. 2015; 15(1):64-7. PMC: 4389099. DOI: 10.5230/jgc.2015.15.1.64. View

Shah S, Sussman D, Jorda M, Ribeiro A . EUS with EMR of an inflammatory myofibroblastic tumor of the stomach. Gastrointest Endosc. 2008; 67(3):561-3. DOI: 10.1016/j.gie.2007.06.031. View

10.

Leon C, Castillo J, Mebold J, Cortez L, Felmer R . Inflammatory myofibroblastic tumor of the stomach: an unusual complication after gastrectomy. Gastrointest Endosc. 2006; 63(2):347-9. DOI: 10.1016/j.gie.2005.09.026. View

11.

Mirshemirani A, Khaleghnejad Tabari A, Sadeghian N, Shariat-Torbaghan S, Pourafkari M, Mohajerzadeh L . Abdominal inflammatory myofibroblastic tumor: report on four cases and review of literature. Iran J Pediatr. 2012; 21(4):543-8. PMC: 3446124. View

12.

Ribeiro M, Lopes L, de Souza Neto J, Meirelles L, Carvalho R, Andreollo N . Rare gastric inflammatory myofibroblastic tumor in an adult woman: a case report with review of the literature. Case Rep Med. 2012; 2012:374070. PMC: 3337595. DOI: 10.1155/2012/374070. View

13.

Cho M, Min Y, Kim N, Cho S, Kim H, Lee K . Fever of unknown origin as a presentation of gastric inflammatory myofibroblastic tumor in a two-year-old boy. J Korean Med Sci. 2002; 17(5):699-703. PMC: 3054930. DOI: 10.3346/jkms.2002.17.5.699. View

14.

Jadhav M, Harvi R, Patil R, Kittur S . Inflammatory Myofibroblastic Tumor of the Stomach Presenting as an Exophytic Mass - A Diagnostic Dilemma. Turk Patoloji Derg. 2017; 35(2):151-156. DOI: 10.5146/tjpath.2017.01388. View

15.

Lee Y, Wang H, Shyung L, Chang C, Chen M . Inflammatory myofibroblastic tumor: an unusual submucosal lesion of the stomach. Endoscopy. 2011; 43 Suppl 2 UCTN:E151-2. DOI: 10.1055/s-0030-1256257. View

16.

Bjelovic M, Micev M, Spica B, Babic T, Gunjic D, Djuric A . Primary inflammatory myofibroblastic tumor of the stomach in an adult woman: a case report and review of the literature. World J Surg Oncol. 2013; 11:35. PMC: 3570320. DOI: 10.1186/1477-7819-11-35. View

17.

Lee D, Suh Y, Lee S . Calcifying fibrous pseudotumour arising in a gastric inflammatory myofibroblastic tumour. Pathology. 2007; 38(6):588-91. View

18.

Nishida T, Blay J, Hirota S, Kitagawa Y, Kang Y . The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines. Gastric Cancer. 2015; 19(1):3-14. PMC: 4688306. DOI: 10.1007/s10120-015-0526-8. View

19.

Shin H, Gu M, Kim S, Kim J, Choi J . Coexistence of gastrointestinal stromal tumor and inflammatory myofibroblastic tumor of the stomach presenting as a collision tumor: first case report and literature review. Diagn Pathol. 2015; 10:181. PMC: 4596292. DOI: 10.1186/s13000-015-0413-y. View

20.

Uno H, Takahara Y, Nishida T, Ohno T, Komatsu T . [A Case of Laparoscopic Local Resection of the Stomach for an Inflammatory Myofibroblastic Tumor]. Gan To Kagaku Ryoho. 2020; 46(13):2054-2056. View