Nutritional Status As a Predictive Factor for Paediatric Tuberous Sclerosis Complex-associated Kidney Angiomyolipomas: a Retrospective Analysis

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2024 Mar 14

PMID 38483608

Authors

Andrew Limavady

Matko Marlais

Affiliations

Soon will be listed here.

Abstract

Conclusions: While gender and genotype are known predictors, this study includes the novel finding of nutritional status as a predictor of TSC-associated kidney disease. This study sheds light on a possible complex interplay of hormonal influences, obesity, and kidney angiomyolipomas growth, and further investigations focusing on the impact of nutritional status on TSC-associated kidney disease are warranted.

What Is Known: • Gender and genotype are well-studied predictive factors in TSC kidney disease.

What Is New: • Nutritional status may influence the development and the progression of kidney lesions in children with TSC and should not be overlooked. • Management guidelines of TSC-associated kidney disease can address nutritional aspects.

Citing Articles

Nutritional status and paediatric tuberous sclerosis complex-associated kidney angiomyolipomas: reply to the commenting letter by Singhvi M et al.

Limavady A, Marlais M Eur J Pediatr. 2024; 184(1):1.

PMID: 39510992 DOI: 10.1007/s00431-024-05838-3.

TSC1 splicing mutation in renal angiomyolipoma with epithelial cysts without fat: A very rare case report and literature review.

Xu Q, Yin L, Tao J, Peng F Heliyon. 2024; 10(14):e34191.

PMID: 39100442 PMC: 11295956. DOI: 10.1016/j.heliyon.2024.e34191.

References

Sun P, Liu J, Charles H, Hulbert J, Bissler J . Outcomes of angioembolization and nephrectomy for renal angiomyolipoma associated with tuberous sclerosis complex: a real-world US national study. Curr Med Res Opin. 2017; 33(5):821-827. DOI: 10.1080/03007995.2017.1286307. View

Kingswood J, Bissler J, Budde K, Hulbert J, Guay-Woodford L, Sampson J . Review of the Tuberous Sclerosis Renal Guidelines from the 2012 Consensus Conference: Current Data and Future Study. Nephron. 2016; 134(2):51-58. DOI: 10.1159/000448293. View

Rakowski S, Winterkorn E, Paul E, Steele D, Halpern E, Thiele E . Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors. Kidney Int. 2006; 70(10):1777-82. DOI: 10.1038/sj.ki.5001853. View

Bissler J, Cappell K, Charles H, Song X, Liu Z, Prestifilippo J . Long-term Clinical Morbidity in Patients With Renal Angiomyolipoma Associated With Tuberous Sclerosis Complex. Urology. 2016; 95:80-7. DOI: 10.1016/j.urology.2016.04.027. View

OCallaghan F, Noakes M, Martyn C, Osborne J . An epidemiological study of renal pathology in tuberous sclerosis complex. BJU Int. 2004; 94(6):853-7. DOI: 10.1111/j.1464-410X.2004.05046.x. View

Kingswood J, Belousova E, Benedik M, Carter T, Cottin V, Curatolo P . Renal angiomyolipoma in patients with tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increase disease Awareness. Nephrol Dial Transplant. 2018; 34(3):502-508. PMC: 6399480. DOI: 10.1093/ndt/gfy063. View

Vargiami E, Stabouli S, Sidira C, Kyriazi M, Anastasiou A, Notopoulos A . Blood pressure and glomerular filtration rate in youth with tuberous sclerosis complex. Eur J Pediatr. 2022; 181(4):1465-1472. DOI: 10.1007/s00431-021-04333-3. View

Kingswood J, Belousova E, Benedik M, Carter T, Cottin V, Curatolo P . Renal Manifestations of Tuberous Sclerosis Complex: Key Findings From the Final Analysis of the TOSCA Study Focussing Mainly on Renal Angiomyolipomas. Front Neurol. 2020; 11:972. PMC: 7526256. DOI: 10.3389/fneur.2020.00972. View

Warncke J, Brodie K, Grantham E, Catarinicchia S, Tong S, Kondo K . Pediatric Renal Angiomyolipomas in Tuberous Sclerosis Complex. J Urol. 2016; 197(2):500-506. DOI: 10.1016/j.juro.2016.09.082. View

10.

Liskiewicz A, Kasprowska D, Wojakowska A, Polanski K, Lewin-Kowalik J, Kotulska K . Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis. Sci Rep. 2016; 6:21807. PMC: 4759602. DOI: 10.1038/srep21807. View

11.

Prizant H, Hammes S . Minireview: Lymphangioleiomyomatosis (LAM): The "Other" Steroid-Sensitive Cancer. Endocrinology. 2016; 157(9):3374-83. PMC: 5007898. DOI: 10.1210/en.2016-1395. View

12.

Bissler J, Kingswood J . Renal manifestation of tuberous sclerosis complex. Am J Med Genet C Semin Med Genet. 2018; 178(3):338-347. DOI: 10.1002/ajmg.c.31654. View

13.

Gallo-Bernal S, Kilcoyne A, Gee M, Paul E . Cystic kidney disease in tuberous sclerosis complex: current knowledge and unresolved questions. Pediatr Nephrol. 2022; 38(10):3253-3264. DOI: 10.1007/s00467-022-05820-x. View

14.

Bertolini F, Casarotti G, Righi L, Bollito E, Albera C, Racca S . Human renal angiomyolipoma cells of male and female origin can migrate and are influenced by microenvironmental factors. PLoS One. 2018; 13(6):e0199371. PMC: 6007918. DOI: 10.1371/journal.pone.0199371. View

15.

Chu-Shore C, Thiele E . Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet. Brain Dev. 2009; 32(4):318-22. DOI: 10.1016/j.braindev.2009.04.009. View

16.

Ariceta G, Buj M, Furlano M, Martinez V, Matamala A, Morales M . Recommendations for the management of renal involvement in the tuberous sclerosis complex. Nefrologia (Engl Ed). 2019; 40(2):142-151. DOI: 10.1016/j.nefro.2019.07.002. View

17.

Sun L, Chao F, Luo B, Ye D, Zhao J, Zhang Q . Impact of Estrogen on the Relationship Between Obesity and Renal Cell Carcinoma Risk in Women. EBioMedicine. 2018; 34:108-112. PMC: 6116349. DOI: 10.1016/j.ebiom.2018.07.010. View

18.

Murray T, Doyle F, Lee M . Transarterial Embolization of Angiomyolipoma: A Systematic Review. J Urol. 2015; 194(3):635-9. DOI: 10.1016/j.juro.2015.04.081. View

19.

Nair N, Chakraborty R, Mahajan Z, Sharma A, Sethi S, Raina R . Renal Manifestations of Tuberous Sclerosis Complex. J Kidney Cancer VHL. 2020; 7(3):5-19. PMC: 7478169. DOI: 10.15586/jkcvhl.2020.131. View

20.

Fernandes S, Demetriades C . The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging. Front Aging. 2022; 2:707372. PMC: 9261424. DOI: 10.3389/fragi.2021.707372. View