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The Impact of Integrating a Low-Lectin Diet with Traditional ADHD Treatments on Gut Microbiota Composition and Symptom Improvement in Children - A Cohort Study

Overview
Publisher Dove Medical Press
Specialty Psychiatry
Date 2024 Mar 14
PMID 38482022
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Abstract

Background And Purpose: This study aimed to investigate the impact of implementing a low-lectin diet on gut microbiota composition and symptom amelioration in pediatric patients diagnosed with Attention Deficit Hyperactivity Disorder (ADHD).

Methods: A total of 58 children (ages 7-15 years), meeting the criteria for ADHD were recruited. In addition to standard medication treatment, participants in the experimental group with a low-lectin diet, while those in the control group received standard medication treatment alone. Clinical outcomes were assessed through evaluations conducted by physicians and teachers, implementation of the Conners Parent Rating Scales, and analysis of gut microbiota composition.

Results: The results revealed significant improvements in symptom reduction and attention allocation rate within the experimental group, surpassing those observed in the control group. Specifically, the experimental group exhibited lower physician ratings, teacher ratings, and attention allocation rate compared to the control group. Moreover, analysis of gut microbiota composition identified notable distinctions between the two groups.

Conclusion: These findings provide compelling evidence and valuable guidance supporting the integration of a low-lectin diet as an adjunctive intervention for managing ADHD.

References
1.
Banwell J, Howard R, Kabir I, Costerton J . Bacterial overgrowth by indigenous microflora in the phytohemagglutinin-fed rat. Can J Microbiol. 1988; 34(8):1009-13. DOI: 10.1139/m88-177. View

2.
Vasconcelos I, Oliveira J . Antinutritional properties of plant lectins. Toxicon. 2004; 44(4):385-403. DOI: 10.1016/j.toxicon.2004.05.005. View

3.
Kanarek R . Artificial food dyes and attention deficit hyperactivity disorder. Nutr Rev. 2011; 69(7):385-91. DOI: 10.1111/j.1753-4887.2011.00385.x. View

4.
Cooper R, Tye C, Kuntsi J, Vassos E, Asherson P . The effect of omega-3 polyunsaturated fatty acid supplementation on emotional dysregulation, oppositional behaviour and conduct problems in ADHD: A systematic review and meta-analysis. J Affect Disord. 2015; 190:474-482. DOI: 10.1016/j.jad.2015.09.053. View

5.
Rios-Hernandez A, Alda J, Farran-Codina A, Ferreira-Garcia E, Izquierdo-Pulido M . The Mediterranean Diet and ADHD in Children and Adolescents. Pediatrics. 2017; 139(2). DOI: 10.1542/peds.2016-2027. View