Desert Dust Episodes During Pregnancy Are Associated with Increased Preterm Delivery in French Guiana

Overview

Journal Front Public Health

Specialty Public Health

Date 2024 Mar 14

PMID 38481831

Authors

Mathieu Nacher

Malika Leneuve

Celia Basurko

Alphonse Louis

Dominique Dotou

Stephanie Bernard

Kathy Pannechou

Karim Merad Boudia

Lindsay Osei

Fabrice Quet

Najeh Hcini

Affiliations

Soon will be listed here.

Abstract

Preterm deliveries are a major multifactorial public health problem in French Guiana. Desert dust episodes have been associated with preterm delivery in Guadeloupe, a territory with similarities to French Guiana. We thus tried to replicate this finding in the context of French Guiana. A retrospective ecological cohort study combined daily PM10 concentration measurements during pregnancy and term at delivery extracted from French Guiana's computerized pregnancy delivery registry. Daily PM10 concentrations during the course of pregnancy were analyzed as mean concentrations and as the proportion of intense dust episodes (≥55 μg PM/m). These exposure variables were studied in relation to the outcome of preterm delivery. Overall, 3,321 pregnant women with complete daily PM10 measurements were included, of whom 374 (11.26%) delivered prematurely. Among preterm deliveries, 168 (44.9%) were spontaneous deliveries and 206 (55.1%) were induced. Rank-sum tests showed that, for spontaneous and induced spontaneous deliveries, both mean PM10 concentrations and proportions of intense desert dust episodes were significantly greater among preterm births than among term births. Although the proportion of intense desert dust episodes during pregnancy was significantly associated with spontaneous preterm deliveries, the relation was U-shaped, with an adjusted odds ratio (AOR) = 2 (95%CI = 1.2-3.1) for lowest values relative to median values and AOR = 5.4 (95%CI = 3.2-8.9) for the highest values relative to median values. Similarly, the proportion of intense desert dust episodes during pregnancy was also significantly associated with induced preterm deliveries in a U-shaped manner (AOR = 2.7 (95%CI = 1.6-4.5) for the lowest relative to median values and AOR = 6.8 (95%CI = 3.9-11.9) for the highest relative to median values). Although in our study the relation between PM10 concentrations appeared non-linear, the highest mean concentrations and intense desert dust episodes were indeed associated with both spontaneous and induced preterm delivery.

References

Duclau A, Abad F, Adenis A, Sabbah N, Leneuve M, Nacher M . Prevalence and risk factors for micronutrient deficiencies during pregnancy in Cayenne, French Guiana. Food Nutr Res. 2021; 65. PMC: 7955516. DOI: 10.29219/fnr.v65.5268. View

Prospero J, Blades E, Naidu R, Mathison G, Thani H, Lavoie M . Relationship between African dust carried in the Atlantic trade winds and surges in pediatric asthma attendances in the Caribbean. Int J Biometeorol. 2008; 52(8):823-32. DOI: 10.1007/s00484-008-0176-1. View

Roberts A, Monzon-Bordonaba F, Van Deerlin P, Holder J, Macones G, Morgan M . Association of polymorphism within the promoter of the tumor necrosis factor alpha gene with increased risk of preterm premature rupture of the fetal membranes. Am J Obstet Gynecol. 1999; 180(5):1297-302. DOI: 10.1016/s0002-9378(99)70632-0. View

Taylor S, Sakurai R, Sakurai T, Rehan V . Inhaled Vitamin D: A Novel Strategy to Enhance Neonatal Lung Maturation. Lung. 2016; 194(6):931-943. PMC: 5191914. DOI: 10.1007/s00408-016-9939-3. View

Klepac P, Locatelli I, Korosec S, Kunzli N, Kukec A . Ambient air pollution and pregnancy outcomes: A comprehensive review and identification of environmental public health challenges. Environ Res. 2018; 167:144-159. DOI: 10.1016/j.envres.2018.07.008. View

Qin L, Lu F, Yang S, Xu H, Luo B . Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies. Nutrients. 2016; 8(5). PMC: 4882713. DOI: 10.3390/nu8050301. View

Viel J, Mallet Y, Raghoumandan C, Quenel P, Kadhel P, Rouget F . Impact of Saharan dust episodes on preterm births in Guadeloupe (French West Indies). Occup Environ Med. 2019; 76(5):336-340. DOI: 10.1136/oemed-2018-105405. View

Alessandrini E, Stafoggia M, Faustini A, Gobbi G, Forastiere F . Saharan dust and the association between particulate matter and daily hospitalisations in Rome, Italy. Occup Environ Med. 2013; 70(6):432-4. DOI: 10.1136/oemed-2012-101182. View

Neophytou A, Yiallouros P, Coull B, Kleanthous S, Pavlou P, Pashiardis S . Particulate matter concentrations during desert dust outbreaks and daily mortality in Nicosia, Cyprus. J Expo Sci Environ Epidemiol. 2013; 23(3):275-80. DOI: 10.1038/jes.2013.10. View

10.

Dadvand P, Basagana X, Figueras F, Amoly E, Tobias A, de Nazelle A . Saharan dust episodes and pregnancy. J Environ Monit. 2011; 13(11):3222-8. DOI: 10.1039/c1em10579e. View

11.

Reyes M, Diaz J, Tobias A, Carlos Montero J, Linares C . Impact of Saharan dust particles on hospital admissions in Madrid (Spain). Int J Environ Health Res. 2013; 24(1):63-72. DOI: 10.1080/09603123.2013.782604. View

12.

Sullivan K, Wooten C, Schmeckpeper B, Goldman D, Petri M . A promoter polymorphism of tumor necrosis factor alpha associated with systemic lupus erythematosus in African-Americans. Arthritis Rheum. 1998; 40(12):2207-11. DOI: 10.1002/art.1780401215. View

13.

Leneuve-Dorilas M, Favre A, Carles G, Louis A, Nacher M . Risk factors for premature birth in French Guiana: the importance of reducing health inequalities. J Matern Fetal Neonatal Med. 2017; 32(8):1388-1396. DOI: 10.1080/14767058.2017.1403578. View

14.

Leneuve-Dorilas M, Favre A, Louis A, Bernard S, Carles G, Nacher M . Risk Factors for Very Preterm Births in French Guiana: The Burden of Induced Preterm Birth. AJP Rep. 2019; 9(1):e44-e53. PMC: 6398999. DOI: 10.1055/s-0039-1678716. View

15.

Karimi S, Pouran H, Majbouri M, Moradi-Lakeh M, Hakimian H . Saharan sand and dust storms and neonatal mortality: Evidence from Burkina Faso. Sci Total Environ. 2020; 729:139053. DOI: 10.1016/j.scitotenv.2020.139053. View

16.

Vadillo-Ortega F, Osornio-Vargas A, Buxton M, Sanchez B, Rojas-Bracho L, Viveros-Alcaraz M . Air pollution, inflammation and preterm birth: a potential mechanistic link. Med Hypotheses. 2014; 82(2):219-24. PMC: 3928635. DOI: 10.1016/j.mehy.2013.11.042. View

17.

Girard E, Nacher M, Bukasa-Kakamba J, Fahrasmane A, Adenis A, Massicard M . Vitamin D Deficiency in Patients with Diabetes in French Guiana: Epidemiology and Relation with Microvascular and Macrovascular Complications. Nutrients. 2021; 13(12). PMC: 8707589. DOI: 10.3390/nu13124302. View

18.

Li X, Huang S, Jiao A, Yang X, Yun J, Wang Y . Association between ambient fine particulate matter and preterm birth or term low birth weight: An updated systematic review and meta-analysis. Environ Pollut. 2017; 227:596-605. DOI: 10.1016/j.envpol.2017.03.055. View

19.

Monteil M . Saharan dust clouds and human health in the English-speaking Caribbean: what we know and don't know. Environ Geochem Health. 2008; 30(4):339-43. DOI: 10.1007/s10653-008-9162-0. View

20.

Stafoggia M, Zauli-Sajani S, Pey J, Samoli E, Alessandrini E, Basagana X . Desert Dust Outbreaks in Southern Europe: Contribution to Daily PM₁₀ Concentrations and Short-Term Associations with Mortality and Hospital Admissions. Environ Health Perspect. 2015; 124(4):413-9. PMC: 4829979. DOI: 10.1289/ehp.1409164. View