Monogenic Kidney Diseases in Kidney Transplantation

Overview

Journal Kidney Int Rep

Publisher Elsevier

Specialty Nephrology

Date 2024 Mar 14

PMID 38481491

Authors

Valentine Gillion

Arnaud Devresse

Eric Olinger

Geraldine Dahlqvist

Nathalie Demoulin

Nathalie Godefroid

Kathleen Claes

Olivier Devuyst

Nada Kanaan

Affiliations

Soon will be listed here.

Abstract

Monogenic kidney diseases are involved in up to 15% of end-stage kidney diseases (ESKDs) in adults, and in 70 % of pediatric patients. When these disorders lead to kidney failure (KF), kidney transplantation (KT) is the preferred mode of replacement therapy. KT requires specific considerations depending on the nature of the genetic disorder, the potential oncological risk, the risk of recurrence in the graft, the possibility of specific complications of immunosuppression, and the issue of living donation. The availability of genetic testing should play an increasing role in the evaluation of patients or related living donor candidates before transplantation, relevant for the pretransplantation and posttransplantation management.

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