Global and Regional Estimates of Tuberculosis Burden Attributed to High Fasting Plasma Glucose from 1990 to 2019: Emphasis on Earlier Glycemic Control

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2024 Mar 14

PMID 38481192

Authors

Qin Bian

Yanjun Zhang

Chen Xue

Wenjing Lu

Wei Li

Fanqi Pan

Yi Li

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have shown subjects suffering from diabetes or persistent hyperglycemia were more likely to develop tuberculosis (TB). However, the global burden of TB attributed to high fasting plasma glucose (HFPG) remains unclear. This study aimed to characterize the global, regional, and national TB burden attributed to HFPG from 1990 to 2019.

Methods: With Global Burden of Disease study 2019, the numbers and age-standardized mortality rates (ASMR) and age-standardized disability-adjusted life years (DALY) rates (ASDR) of TB attributed to HFPG at global, regional, and national levels from 1990 to 2019 were extracted. The locally weighted regression model was applied to estimate the TB burden for different socio-demographic index (SDI) regions.

Results: Globally, the ASMR and ASDR attributed to HFPG were 2.70 (95% UI, 1.64-3.94) and 79.70 (95% UI, 50.26-112.51) per 100,000 population in 1990, respectively. These rates decreased to 1.46 (95% UI, 0.91-2.08) and 45.53 (95% UI, 29.06-62.29) in 2019. The TB burden attributed to HFPG remained high in low SDI and Central Sub-Saharan Africa regions, while it declined with most significantly in high SDI and East Asia regions. Additionally, the ASMR and ASDR of TB attributed to HFPG were significantly higher in the male and the elderly population.

Conclusions: The global TB burden attributable to HFPG decreased from 1990 to 2019, but remained high in low SDI regions among high-risk populations. Thus, urgent efforts are required to enhance the awareness of early glycemic control and TB treatment to alleviate the severe situation.

Citing Articles

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PMID: 40069759 PMC: 11900396. DOI: 10.1186/s12889-025-21793-6.

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