Association of High-sensitivity CRP and FEV1%pred: a Study on Non-pulmonary Disease in a Population in Beijing, China

Overview

Journal BMJ Open Respir Res

Date 2024 Mar 13

PMID 38479820

Authors

Xiaoyu Yang

Jiping Liao

Sainan Zhu

Cheng Zhang

Xiaoyu Ma

Chunbo Zhang

Yunxia Wang

Kunyan Sun

Guangfa Wang

Affiliations

Soon will be listed here.

Abstract

Background: No studies have investigated whether high-sensitivity C reactive protein (hsCRP) can be used to predict the forced expiratory volume in 1 s (FEV1)/estimated value of FEV1 (FEV1%pred). This study aimed to assess the association between hsCRP and FEV1%pred in middle-aged and elderly individuals without underlying lung disease.

Methods: The data for this study were obtained from a prospective cohort study that included 1047 middle-aged and elderly citizens from Beijing aged 40-75 years without any evidence of underlying lung diseases with FEV1 >70% after receiving inhalational bronchodilators. The baseline analysis of the participants was performed from 30 May 2018 to 31 October 2018. Restricted cubic spline regression and multivariate linear regression models were used to assess the non-linear association and linear association between hsCRP and FEV1/FEV in 6 s (FEV6) and FEV1%pred, respectively.

Results: The hsCRP values of 851 participants were recorded; the values were normal in 713 (83.8%) participants. The remaining 196 participants (18.7%) had missing data. A non-linear association was observed between normal hsCRP values and FEV1/FEV6. hsCRP was linearly and negatively correlated with FEV1%pred, and each 1 SD increase in hsCRP was significantly associated with a 2.4% lower in FEV1%pred. Significantly higher FEV1/FEV6 differences were observed in the female subgroup than those in the male subgroup (p=0.011 for interaction).

Conclusions: hsCRP had a non-linear association with FEV1/FEV6 and a linear negative association with FEV1%pred in individuals with normal hsCRP values. hsCRP can be used to predict FEV1%pred, which can be used to predict the development of chronic obstructive pulmonary disease. hsCRP has a stronger association with lung function in women than that in men.

Trial Registration Number: NCT03532893.

References

Olafsdottir I, Gislason T, Thjodleifsson B, Olafsson I, Gislason D, Jogi R . Gender differences in the association between C-reactive protein, lung function impairment, and COPD. Int J Chron Obstruct Pulmon Dis. 2008; 2(4):635-42. PMC: 2699969. View

Aronson D, Roterman I, Yigla M, Kerner A, Avizohar O, Sella R . Inverse association between pulmonary function and C-reactive protein in apparently healthy subjects. Am J Respir Crit Care Med. 2006; 174(6):626-32. DOI: 10.1164/rccm.200602-243OC. View

Glaser S, Ittermann T, Koch B, Volzke H, Wallaschofski H, Nauck M . Airflow limitation, lung volumes and systemic inflammation in a general population. Eur Respir J. 2011; 39(1):29-37. DOI: 10.1183/09031936.00009811. View

Represas Represas C, Botana Rial M, Leiro Fernandez V, Gonzalez Silva A, Perez V, Fernandez-Villar A . [Assessment of the portable COPD-6 device for detecting obstructive airway diseases]. Arch Bronconeumol. 2010; 46(8):426-32. DOI: 10.1016/j.arbres.2010.04.008. View

van Durme Y, Verhamme K, Aarnoudse A, van Pottelberge G, Hofman A, Witteman J . C-reactive protein levels, haplotypes, and the risk of incident chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008; 179(5):375-82. DOI: 10.1164/rccm.200810-1540OC. View

Shaaban R, Kony S, Driss F, Leynaert B, Soussan D, Pin I . Change in C-reactive protein levels and FEV1 decline: a longitudinal population-based study. Respir Med. 2006; 100(12):2112-20. DOI: 10.1016/j.rmed.2006.03.027. View

Gimeno D, Delclos G, Ferrie J, De Vogli R, Elovainio M, Marmot M . Association of CRP and IL-6 with lung function in a middle-aged population initially free from self-reported respiratory problems: the Whitehall II study. Eur J Epidemiol. 2011; 26(2):135-44. PMC: 3199309. DOI: 10.1007/s10654-010-9526-5. View

Jakeways N, McKeever T, Lewis S, Weiss S, Britton J . Relationship between FEV1 reduction and respiratory symptoms in the general population. Eur Respir J. 2003; 21(4):658-63. DOI: 10.1183/09031936.03.00069603. View

Quanjer P, Stanojevic S, Cole T, Baur X, Hall G, Culver B . Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012; 40(6):1324-43. PMC: 3786581. DOI: 10.1183/09031936.00080312. View

10.

Lee H, Le T, Lopez V, Wong N . Association of C-reactive protein with reduced forced vital capacity in a nonsmoking U.S. population with metabolic syndrome and diabetes. Diabetes Care. 2008; 31(10):2000-2. PMC: 2551643. DOI: 10.2337/dc08-0801. View

11.

Hancox R, Poulton R, Greene J, Filsell S, McLachlan C, Rasmussen F . Systemic inflammation and lung function in young adults. Thorax. 2007; 62(12):1064-8. PMC: 2094275. DOI: 10.1136/thx.2006.076877. View

12.

Vandevoorde J, Verbanck S, Schuermans D, Kartounian J, Vincken W . FEV1/FEV6 and FEV6 as an alternative for FEV1/FVC and FVC in the spirometric detection of airway obstruction and restriction. Chest. 2005; 127(5):1560-4. DOI: 10.1378/chest.127.5.1560. View

13.

Prescott E, Bjerg A, Andersen P, Lange P, Vestbo J . Gender difference in smoking effects on lung function and risk of hospitalization for COPD: results from a Danish longitudinal population study. Eur Respir J. 1997; 10(4):822-7. View

14.

Dahl M, Vestbo J, Zacho J, Lange P, Tybjaerg-Hansen A, Nordestgaard B . C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach. Thorax. 2010; 66(3):197-204. DOI: 10.1136/thx.2009.131193. View

15.

Yoo B, Lee S, Kim S, Leem A, Chung K, Kim E . Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea. Int J Tuberc Lung Dis. 2019; 23(11):1228-1234. DOI: 10.5588/ijtld.18.0848. View

16.

Maestrelli P, Saetta M, Mapp C, Fabbri L . Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001; 164(10 Pt 2):S76-80. DOI: 10.1164/ajrccm.164.supplement_2.2106067. View

17.

Jiang R, Burke G, Enright P, Newman A, Margolis H, Cushman M . Inflammatory markers and longitudinal lung function decline in the elderly. Am J Epidemiol. 2008; 168(6):602-10. PMC: 2727196. DOI: 10.1093/aje/kwn174. View

18.

Jung D, Shim J, Ahn H, Lee H, Lee J, Lee Y . Relationship of body composition and C-reactive protein with pulmonary function. Respir Med. 2010; 104(8):1197-203. DOI: 10.1016/j.rmed.2010.02.014. View

19.

Fuertes E, Carsin A, Garcia-Larsen V, Guerra S, Pin I, Leynaert B . The role of C-reactive protein levels on the association of physical activity with lung function in adults. PLoS One. 2019; 14(9):e0222578. PMC: 6756522. DOI: 10.1371/journal.pone.0222578. View

20.

Fogarty A, Jones S, Britton J, Lewis S, McKeever T . Systemic inflammation and decline in lung function in a general population: a prospective study. Thorax. 2007; 62(6):515-20. PMC: 2117221. DOI: 10.1136/thx.2006.066969. View