The Maternal Omega-3 Long-Chain Polyunsaturated Fatty Acid Concentration in Early Pregnancy and Infant Neurodevelopment: The ECLIPSES Study

Overview

Journal Nutrients

Date 2024 Mar 13

PMID 38474815

Authors

Behnaz Shahabi

Carmen Hernandez-Martinez

Nuria Voltas

Josefa Canals

Victoria Arija

Affiliations

Soon will be listed here.

Abstract

Omega-3 Long-Chain Polyunsaturated Fatty Acids (-3 LCPUFAs) play a key role in early neurodevelopment, but evidence from observational and clinical studies remains inconsistent. This study investigates the association between maternal -3 LCPUFA, Docosahexaenoic Acid (DHA), and eicosapentaenoic acid (EPA) concentrations during pregnancy and infant development functioning at 40 days. This study includes 348 mother-infant pairs. Maternal serum concentrations were assessed in the first and third trimesters alongside sociodemographic, clinical, nutritional, psychological, and obstetrical data. At 40 days, the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) was administered. An adjusted analysis revealed that lower first-trimester -3 LCPUFA and DHA concentrations are associated with better infant motor development. These results underscore the potential significance of the maternal -3 LCPUFA status in early pregnancy for influencing fetal neurodevelopment. However, the complexity of these associations necessitates further investigation, emphasizing the urgent need for additional studies to comprehensively elucidate the nuanced interplay between the maternal -3 LCPUFA status and infant neurodevelopment.

Citing Articles

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