Exploring the Dynamic Relationship Between the Gut Microbiome and Body Composition Across the Human Lifespan: A Systematic Review

Overview

Journal Nutrients

Date 2024 Mar 13

PMID 38474787

Authors

Ifigeneia Komodromou

Eleni Andreou

Angelos Vlahoyiannis

Maria Christofidou

Kyriacos Felekkis

Myrtani Pieri

Christoforos D Giannaki

Affiliations

Soon will be listed here.

Abstract

This systematic review aimed to identify different gut microbiome profiles across the human lifespan and to correlate such profiles with the body composition. PubMed, Scopus, and Cochrane were searched from inception to March 2022. Sixty studies were included in this systematic review. Overall, the gut microbiome composition in overweight participants exhibited decreased α-diversity, decreased levels of the phylum and its taxa, and increased levels of the phylum , its taxa, and the / ratio, in comparison to normal-weight participants. Other body composition parameters showed similar correlations. Fat mass and waist circumference were found to correlate positively with the taxa and negatively with the taxa. In contrast, lean body mass and muscle mass demonstrated a positive correlation with the taxa. Notably, these correlations were more pronounced in athletes than in obese and normal-weight individuals. The composition of the gut microbiome is evidently different in overweight individuals or athletes of all age groups, with the former tending towards decreased taxa and increased taxa, while a reversed relationship is observed concerning athletes. Further studies are needed to explore the dynamic relationship between energy intake, body composition, and the gut microbiome across the human lifespan.

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References

Janssens P, Penders J, Hursel R, Budding A, Savelkoul P, Westerterp-Plantenga M . Long-Term Green Tea Supplementation Does Not Change the Human Gut Microbiota. PLoS One. 2016; 11(4):e0153134. PMC: 4824458. DOI: 10.1371/journal.pone.0153134. View

Radua J . PRISMA 2020 - An updated checklist for systematic reviews and meta-analyses. Neurosci Biobehav Rev. 2021; 124:324-325. DOI: 10.1016/j.neubiorev.2021.02.016. View

Valeriani F, Galle F, Cattaruzza M, Antinozzi M, Gianfranceschi G, Postiglione N . Are nutrition and physical activity associated with gut microbiota? A pilot study on a sample of healthy young adults. Ann Ig. 2020; 32(5):521-527. DOI: 10.7416/ai.2020.2372. View

Appleton J . The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health. Integr Med (Encinitas). 2019; 17(4):28-32. PMC: 6469458. View

Most J, Penders J, LUCCHESI M, Goossens G, Blaak E . Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women. Eur J Clin Nutr. 2017; 71(9):1040-1045. DOI: 10.1038/ejcn.2017.89. View

Davis C . The Gut Microbiome and Its Role in Obesity. Nutr Today. 2016; 51(4):167-174. PMC: 5082693. DOI: 10.1097/NT.0000000000000167. View

Teixeira T, Grzeskowiak L, Salminen S, Laitinen K, Bressan J, Gouveia Peluzio M . Faecal levels of Bifidobacterium and Clostridium coccoides but not plasma lipopolysaccharide are inversely related to insulin and HOMA index in women. Clin Nutr. 2013; 32(6):1017-22. DOI: 10.1016/j.clnu.2013.02.008. View

Riva A, Borgo F, Lassandro C, Verduci E, Morace G, Borghi E . Pediatric obesity is associated with an altered gut microbiota and discordant shifts in Firmicutes populations. Environ Microbiol. 2016; 19(1):95-105. PMC: 5516186. DOI: 10.1111/1462-2920.13463. View

Basciani S, Camajani E, Contini S, Persichetti A, Risi R, Bertoldi L . Very-Low-Calorie Ketogenic Diets With Whey, Vegetable, or Animal Protein in Patients With Obesity: A Randomized Pilot Study. J Clin Endocrinol Metab. 2020; 105(9). DOI: 10.1210/clinem/dgaa336. View

10.

Kulecka M, Fraczek B, Mikula M, Zeber-Lubecka N, Karczmarski J, Paziewska A . The composition and richness of the gut microbiota differentiate the top Polish endurance athletes from sedentary controls. Gut Microbes. 2020; 11(5):1374-1384. PMC: 7524299. DOI: 10.1080/19490976.2020.1758009. View

11.

Ortiz-Alvarez L, Xu H, Martinez-Tellez B . Influence of Exercise on the Human Gut Microbiota of Healthy Adults: A Systematic Review. Clin Transl Gastroenterol. 2020; 11(2):e00126. PMC: 7145029. DOI: 10.14309/ctg.0000000000000126. View

12.

Cornejo-Pareja I, Munoz-Garach A, Clemente-Postigo M, Tinahones F . Importance of gut microbiota in obesity. Eur J Clin Nutr. 2018; 72(Suppl 1):26-37. DOI: 10.1038/s41430-018-0306-8. View

13.

Chen F, Li Q, Chen Y, Wei Y, Liang J, Song Y . Association of the gut microbiota and fecal short-chain fatty acids with skeletal muscle mass and strength in children. FASEB J. 2021; 36(1):e22109. DOI: 10.1096/fj.202002697RRR. View

14.

McCann J, Bihlmeyer N, Roche K, Catherine C, Jawahar J, Kwee L . The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights. Obesity (Silver Spring). 2021; 29(3):569-578. PMC: 7927749. DOI: 10.1002/oby.23081. View

15.

Gomes A, Hoffmann C, Mota J . The human gut microbiota: Metabolism and perspective in obesity. Gut Microbes. 2018; 9(4):308-325. PMC: 6219651. DOI: 10.1080/19490976.2018.1465157. View

16.

Lopez-Contreras B, Moran-Ramos S, Villarruel-Vazquez R, Macias-Kauffer L, Villamil-Ramirez H, Leon-Mimila P . Composition of gut microbiota in obese and normal-weight Mexican school-age children and its association with metabolic traits. Pediatr Obes. 2018; 13(6):381-388. DOI: 10.1111/ijpo.12262. View

17.

Maruvada P, Leone V, Kaplan L, Chang E . The Human Microbiome and Obesity: Moving beyond Associations. Cell Host Microbe. 2017; 22(5):589-599. DOI: 10.1016/j.chom.2017.10.005. View

18.

Walters W, Xu Z, Knight R . Meta-analyses of human gut microbes associated with obesity and IBD. FEBS Lett. 2014; 588(22):4223-33. PMC: 5050012. DOI: 10.1016/j.febslet.2014.09.039. View

19.

Lopez-Siles M, Duncan S, Garcia-Gil L, Martinez-Medina M . Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics. ISME J. 2017; 11(4):841-852. PMC: 5364359. DOI: 10.1038/ismej.2016.176. View

20.

Tamura M, Hoshi C, Kobori M, Takahashi S, Tomita J, Nishimura M . Quercetin metabolism by fecal microbiota from healthy elderly human subjects. PLoS One. 2017; 12(11):e0188271. PMC: 5703521. DOI: 10.1371/journal.pone.0188271. View