Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Genus

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Mar 13

PMID 38474596

Authors

Sarai Rojas-Jimenez

Maria Guadalupe Valladares-Cisneros

David Osvaldo Salinas-Sanchez

Julia Perez-Ramos

Leonor Sanchez-Perez

Salud Perez-Gutierrez

Nimsi Campos-Xolalpa

Affiliations

Soon will be listed here.

Abstract

is a large genus of the Euphorbiaceae family. Around 250 species of the genus have been studied chemically and pharmacologically; different compounds have been isolated from these species, especially diterpenes and triterpenes. Several reports show that several species have anti-inflammatory activity, which can be attributed to the presence of diterpenes, such as abietanes, ingenanes, and lathyranes. In addition, it was found that some diterpenes isolated from different species have anti-cancer activity. In this review, we included compounds isolated from species of the genus with anti-inflammatory or cytotoxic effects published from 2018 to September 2023. The databases used for this review were Science Direct, Scopus, PubMed, Springer, and Google Scholar, using the keywords with anti-inflammatory or cytotoxic activity. In this review, 68 studies were collected and analyzed regarding the anti-inflammatory and anti-cancer activities of 264 compounds obtained from 36 species of the genus. The compounds included in this review are terpenes (95%), of which 68% are diterpenes, especially of the types ingenanes, abietanes, and triterpenes (approximately 15%).

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