Communication Between Mast Cells and Group 2 Innate Lymphoid Cells in the Skin

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2024 Mar 13

PMID 38474426

Authors

Yeganeh Mehrani

Solmaz Morovati

Tahmineh Tajik

Soroush Sarmadi

Ali Bitaraf

Zahra Sourani

Mohammad Shahverdi

Helia Javadi

Julia E Kakish

Byram W Bridle

Khalil Karimi

Affiliations

Soon will be listed here.

Abstract

The skin is a dynamic organ with a complex immune network critical for maintaining balance and defending against various pathogens. Different types of cells in the skin, such as mast cells (MCs) and group 2 innate lymphoid cells (ILC2s), contribute to immune regulation and play essential roles in the early immune response to various triggers, including allergens. It is beneficial to dissect cell-to-cell interactions in the skin to elucidate the mechanisms underlying skin immunity. The current manuscript concentrates explicitly on the communication pathways between MCs and ILC2s in the skin, highlighting their ability to regulate immune responses, inflammation, and tissue repair. Furthermore, it discusses how the interactions between MCs and ILC2s play a crucial role in various skin conditions, such as autoimmune diseases, dermatological disorders, and allergic reactions. Understanding the complex interactions between MCs and ILC2s in different skin conditions is crucial to developing targeted treatments for related disorders. The discovery of shared pathways could pave the way for novel therapeutic interventions to restore immunological balance in diseased skin tissues.

Citing Articles

CREB Is Critically Implicated in Skin Mast Cell Degranulation Elicited via FcεRI and MRGPRX2.

Li Z, Schneikert J, Tripathi S, Jin M, Bal G, Zuberbier T Cells. 2024; 13(20.

PMID: 39451199 PMC: 11506305. DOI: 10.3390/cells13201681.

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