As a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Mar 13

PMID 38474254

Authors

Ana Isabel Beltran-Velasco

Manuel Reiriz

Sara Uceda

Victor Echeverry-Alzate

Affiliations

Soon will be listed here.

Abstract

This systematic review addresses the use of ( in the symptomatological intervention of neurodegenerative disease. The existence of gut microbiota dysbiosis has been associated with systemic inflammatory processes present in neurodegenerative disease, creating the opportunity for new treatment strategies. This involves modifying the strains that constitute the gut microbiota to enhance synaptic function through the gut-brain axis. Recent studies have evaluated the beneficial effects of the use of on motor and cognitive symptomatology, alone or in combination. This systematic review includes 20 research articles ( = 3 in human and = 17 in animal models). The main result of this research was that the use of alone or in combination produced improvements in symptomatology related to neurodegenerative disease. However, one of the studies included reported negative effects after the administration of . This systematic review provides current and relevant information about the use of this probiotic in pathologies that present neurodegenerative processes such as Alzheimer's disease, Parkinson's disease and Multiple Sclerosis.

Citing Articles

Gut-Brain Axis and Brain Microbiome Interactions from a Medical Perspective.

Arneth B Brain Sci. 2025; 15(2).

PMID: 40002500 PMC: 11853140. DOI: 10.3390/brainsci15020167.

and Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review.

Reiriz M, Beltran-Velasco A, Echeverry-Alzate V, Martinez-Miguel E, Gomez-Senent S, Uceda S Nutrients. 2025; 17(3).

PMID: 39940249 PMC: 11820578. DOI: 10.3390/nu17030391.

Unveiling the whole genomic features and potential probiotic characteristics of novel HMX2.

Aziz T, Naveed M, Shabbir M, Sarwar A, Naseeb J, Zhao L Front Microbiol. 2024; 15:1504625.

PMID: 39611087 PMC: 11602494. DOI: 10.3389/fmicb.2024.1504625.

Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review.

Munteanu C, Galaction A, Turnea M, Blendea C, Rotariu M, Postaru M Antioxidants (Basel). 2024; 13(9).

PMID: 39334720 PMC: 11429174. DOI: 10.3390/antiox13091062.

Implications of Butyrate Signaling Pathways on the Motor Symptomatology of Parkinson's Disease and Neuroprotective Effects-Therapeutic Approaches: A Systematic Review.

Missiego-Beltran J, Olalla-Alvarez E, Gonzalez-Brugera A, Beltran-Velasco A Int J Mol Sci. 2024; 25(16).

PMID: 39201684 PMC: 11354563. DOI: 10.3390/ijms25168998.

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