Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Mar 13

PMID 38474047

Authors

A Khoo

M Boyer

Z Jafri

T Makeham

T Pham

L M Khachigian

P Floros

E Dowling

K Fedder

D Shonka Jr

J Garneau

C H OMeara

Affiliations

Soon will be listed here.

Abstract

Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck squamous cell carcinoma (HNSCC), involves the palatine tonsils, soft palate, base of tongue, and uvula, with the ability to spread to adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated squamous cell carcinoma of the oropharynx (HPVOPSCC) are yet to be established. In this article, we summarise our current understanding of the pathogenesis of HPVOPSCC, the intrinsic role of the immune system, current ICI clinical trials, and the potential role of small molecule immunotherapy in HPVOPSCC.

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