Mast Cells in Autism Spectrum Disorder-The Enigma to Be Solved?

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Mar 13

PMID 38473898

Authors

Eleonora Kovacheva

Maria Gevezova

Michael Maes

Victoria Sarafian

Affiliations

Soon will be listed here.

Abstract

Autism Spectrum Disorder (ASD) is a disturbance of neurodevelopment with a complicated pathogenesis and unidentified etiology. Many children with ASD have a history of "allergic symptoms", often in the absence of mast cell (MC)-positive tests. Activation of MCs by various stimuli may release molecules related to inflammation and neurotoxicity, contributing to the development of ASD. The aim of the present paper is to enrich the current knowledge on the relationship between MCs and ASD by discussing key molecules and immune pathways associated with MCs in the pathogenesis of autism. Cytokines, essential marker molecules for MC degranulation and therapeutic targets, are also highlighted. Understanding the relationship between ASD and the activation of MCs, as well as the involved molecules and interactions, are the main points contributing to solving the enigma. Key molecules, associated with MCs, may provide new insights to the discovery of drug targets for modeling inflammation in ASD.

References

Sahin M . Targeted treatment trials for tuberous sclerosis and autism: no longer a dream. Curr Opin Neurobiol. 2012; 22(5):895-901. PMC: 3715752. DOI: 10.1016/j.conb.2012.04.008. View

Patel S, Cooper M, Jones H, Whitehouse A, Dale R, Guastella A . Maternal immune-related conditions during pregnancy may be a risk factor for neuropsychiatric problems in offspring throughout childhood and adolescence. Psychol Med. 2020; 51(16):2904-2914. DOI: 10.1017/S0033291720001580. View

Arvola T, Ruuska T, Keranen J, Hyoty H, Salminen S, Isolauri E . Rectal bleeding in infancy: clinical, allergological, and microbiological examination. Pediatrics. 2006; 117(4):e760-8. DOI: 10.1542/peds.2005-1069. View

Jyonouchi H, Sun S, Le H . Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 2001; 120(1-2):170-9. DOI: 10.1016/s0165-5728(01)00421-0. View

Russo M, Moccia S, Spagnuolo C, Tedesco I, Russo G . Roles of flavonoids against coronavirus infection. Chem Biol Interact. 2020; 328:109211. PMC: 7385538. DOI: 10.1016/j.cbi.2020.109211. View

Church M, Gradidge C . Potentiation of histamine release by sodium cromoglycate. Life Sci. 1978; 23(19):1899-903. DOI: 10.1016/0024-3205(78)90555-6. View

Vieira Dos Santos R, Magerl M, Martus P, Zuberbier T, Church M, Escribano L . Topical sodium cromoglicate relieves allergen- and histamine-induced dermal pruritus. Br J Dermatol. 2009; 162(3):674-6. DOI: 10.1111/j.1365-2133.2009.09516.x. View

Van Aller G, Carson J, Tang W, Peng H, Zhao L, Copeland R . Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochem Biophys Res Commun. 2011; 406(2):194-9. DOI: 10.1016/j.bbrc.2011.02.010. View

Angelidou A, Asadi S, Alysandratos K, Karagkouni A, Kourembanas S, Theoharides T . Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012; 12:89. PMC: 3496584. DOI: 10.1186/1471-2431-12-89. View

10.

Beversdorf D, Stevens H, Margolis K, Van de Water J . Prenatal Stress and Maternal Immune Dysregulation in Autism Spectrum Disorders: Potential Points for Intervention. Curr Pharm Des. 2019; 25(41):4331-4343. PMC: 7100710. DOI: 10.2174/1381612825666191119093335. View

11.

Nelson P, Kuddo T, Song E, Dambrosia J, Kohler S, Satyanarayana G . Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. Int J Dev Neurosci. 2005; 24(1):73-80. DOI: 10.1016/j.ijdevneu.2005.10.003. View

12.

Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen L . Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol. 2008; 204(1-2):149-53. PMC: 2615583. DOI: 10.1016/j.jneuroim.2008.07.006. View

13.

Suh H, Zhao M, Derico L, Choi N, Lee S . Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators. J Neuroinflammation. 2013; 10:37. PMC: 3607995. DOI: 10.1186/1742-2094-10-37. View

14.

Chez M, Dowling T, Patel P, Khanna P, Kominsky M . Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatr Neurol. 2007; 36(6):361-5. DOI: 10.1016/j.pediatrneurol.2007.01.012. View

15.

Tsilioni I, Panagiotidou S, Theoharides T . Exosomes in neurologic and psychiatric disorders. Clin Ther. 2014; 36(6):882-8. DOI: 10.1016/j.clinthera.2014.05.005. View

16.

Zhang X, Wang Y, Dong H, Xu Y, Zhang S . Induction of Microglial Activation by Mediators Released from Mast Cells. Cell Physiol Biochem. 2016; 38(4):1520-31. DOI: 10.1159/000443093. View

17.

Donelan J, Boucher W, Papadopoulou N, Lytinas M, Papaliodis D, Dobner P . Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process. Proc Natl Acad Sci U S A. 2006; 103(20):7759-64. PMC: 1472518. DOI: 10.1073/pnas.0602210103. View

18.

Theoharides T, Doyle R, Francis K, Conti P, Kalogeromitros D . Novel therapeutic targets for autism. Trends Pharmacol Sci. 2008; 29(8):375-82. DOI: 10.1016/j.tips.2008.06.002. View

19.

Chen H, Jin Z, Wang X, Xu X, Deng L, Zhao J . Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neurosci Lett. 2008; 448(2):175-9. DOI: 10.1016/j.neulet.2008.10.046. View

20.

Li X, Chauhan A, Sheikh A, Patil S, Chauhan V, Li X . Elevated immune response in the brain of autistic patients. J Neuroimmunol. 2009; 207(1-2):111-6. PMC: 2770268. DOI: 10.1016/j.jneuroim.2008.12.002. View