Bisphenol A: Unveiling Its Role in Glioma Progression and Tumor Growth

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Mar 13

PMID 38473752

Authors

Liang Niu

Juan Jia

Hu Yang

Shangyu Liu

Hongyu Wang

Yunji Yan

Qiao Li

Qiang Dong

He Zhang

Guoming Zhao

Junqiang Dai

Guoqiang Yuan

Yawen Pan

Affiliations

Soon will be listed here.

Abstract

Gliomas represent the most common and lethal category of primary brain tumors. Bisphenol A (BPA), a widely recognized endocrine disruptor, has been implicated in the progression of cancer. Despite its established links to various cancers, the association between BPA and glioma progression remains to be clearly defined. This study aimed to shed light on the impact of BPA on glioma cell proliferation and overall tumor progression. Our results demonstrate that BPA significantly accelerates glioma cell proliferation in a time- and dose-dependent manner. Furthermore, BPA has been found to enhance the invasive and migratory capabilities of glioma cells, potentially promoting epithelial-mesenchymal transition (EMT) characteristics within these tumors. Employing bioinformatics approaches, we devised a risk assessment model to gauge the potential glioma hazards associated with BPA exposure. Our comprehensive analysis revealed that BPA not only facilitates glioma invasion and migration but also inhibits apoptotic processes. In summary, our study offers valuable insights into the mechanisms by which BPA may promote tumorigenesis in gliomas, contributing to the understanding of its broader implications in oncology.

Citing Articles

Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer.

Huang C, Xie R, Li P, Chen C, You B, Sun Y Int J Mol Sci. 2025; 26(2).

PMID: 39859529 PMC: 11766120. DOI: 10.3390/ijms26020814.

Bisphenol A-What Do We Know? A Global or Local Approach at the Public Health Risk Level.

Charkiewicz A, Omeljaniuk W, Niklinski J Int J Mol Sci. 2024; 25(11).

PMID: 38892416 PMC: 11172700. DOI: 10.3390/ijms25116229.

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