A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of P16-Positive Versus P16-Negative Oropharyngeal Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2024 Mar 13

PMID 38473308

Authors

Alexandru Chioreanu

Nicolae Constatin Balica

Cristian Ion Mot

Radmila Bugari

Raluca Morar

Flavia Baderca

Teodora Daniela Marti

Casiana Boru

Cecilia Roberta Avram

Sorin Dema

Dan Dumitru Vulcanescu

Delia Ioana Horhat

Affiliations

Soon will be listed here.

Abstract

Background: Oropharyngeal cancer is a global health concern due to its multifaceted nature. Recent molecular studies have linked p16 overexpression, associated with the human papillomavirus, to oropharyngeal cancer and its prognostic implications.

Materials And Methods: This retrospective study in Western Romania examined 60 patients, categorizing them based on p16 biomarker status: 28 were p16 positive, and 32 were p16 negative. Statistical tests, including Fisher's exact and chi2, were used for analysis.

Results: Patients with p16-positive oropharyngeal cancer exhibited a better prognosis (3-year survival, = 0.0477; midtreatment, = 0.0349) and reported lower alcohol ( = 0.0046) and tobacco ( < 0.0001) use.

Conclusions: The study highlights the importance of p16 testing in oropharyngeal carcinoma diagnosis. It suggests modifying treatment approaches based on p16 status and underscores the differing prognoses associated with p16-positive and p16-negative cases.

Citing Articles

Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study.

Boscolo-Rizzo P, Polesel J, Menegaldo A, Sia E, Stellin M, Tirelli G Head Neck Pathol. 2024; 18(1):101.

PMID: 39404976 PMC: 11480278. DOI: 10.1007/s12105-024-01713-7.

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