Ten-year Trends in Values of Joint Space Width and Osteophyte Area of Knee Joints: Comparison of the Baseline and Fourth ROAD Study Surveys

Overview

Journal Osteoarthr Cartil Open

Date 2024 Mar 12

PMID 38469555

Authors

Banri Kitamura

Toshiko Iidaka

Chiaki Horii

Shigeyuki Muraki

Hiroyuki Oka

Hiroshi Kawaguchi

Kozo Nakamura

Toru Akune

Yuta Otsuka

Takayuki Izumo

Takao Tanaka

Tomohiro Rogi

Hiroshi Shibata

Sakae Tanaka

Noriko Yoshimura

Affiliations

Soon will be listed here.

Abstract

Objective: Considering the joint space width and osteophyte area (OPA) of the knee joints of Japanese adults, this study elucidated the ten-year trends in medial minimum joint space width (mJSW) and OPA using data of two independent cohorts from a population-based cohort study.

Methods: The baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability study was conducted from 2005 to 2007; 2975 participants (1041 men, 1934 women) completed all knee osteoarthritis (OA) examinations. The fourth survey was performed from 2015 to 2016; distinct 2445 participants (764 men, 1681 women) completed identical examinations. The medial mJSW and medial tibial OPA were measured bilaterally using an automated system.

Results: The mean medial mJSW (standard deviation) was 3.22 (0.96) mm and 2.65 (0.95) mm at baseline and 3.81 (1.20) mm and 3.13 (1.15) mm in the fourth survey for men and women, respectively. The mean medial mJSW in the fourth survey was significantly greater in both men and women in all age groups than at baseline ( < 0.01). The mean OPAs in men aged 40-49 and 60-69 years and women aged 40-49, 50-59, 60-69, and 70-79 years were significantly smaller in the fourth survey ( < 0.05). The trend in mJSW remained the same even after adjusting for confounding factors in the multivariate analysis, but the trend in OPA was weakened.

Conclusions: A significant improvement in the medial mJSW within 10 years could decrease the incidence and progression of knee OA and prevent the risk of walking disability.

Citing Articles

Trends in knee osteoarthritis prevalence over a 10-year period in Japan: The ROAD study 2005-2015.

Tanegashima G, Iidaka T, Muraki S, Horii C, Oka H, Kawaguchi H Osteoarthr Cartil Open. 2025; 7(1):100569.

PMID: 39968102 PMC: 11834036. DOI: 10.1016/j.ocarto.2025.100569.

References

Chan O, van Houwelingen A, Gussekloo J, Blom J, den Elzen W . Comparison of quadriceps strength and handgrip strength in their association with health outcomes in older adults in primary care. Age (Dordr). 2014; 36(5):9714. PMC: 4185022. DOI: 10.1007/s11357-014-9714-4. View

Bohannon R, Magasi S, Bubela D, Wang Y, Gershon R . Grip and knee extension muscle strength reflect a common construct among adults. Muscle Nerve. 2012; 46(4):555-8. PMC: 3448119. DOI: 10.1002/mus.23350. View

Iidaka T, Horii C, Muraki S, Oka H, Kawaguchi H, Nakamura K . Trends in prevalence of hip osteoarthritis over a 10-year period in Japan: The ROAD study 2005-2015. Osteoarthr Cartil Open. 2022; 4(3):100285. PMC: 9718137. DOI: 10.1016/j.ocarto.2022.100285. View

Amin S, Baker K, Niu J, Clancy M, Goggins J, Guermazi A . Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis. Arthritis Rheum. 2009; 60(1):189-98. PMC: 3653642. DOI: 10.1002/art.24182. View

Muraki S, Akune T, En-yo Y, Yoshida M, Tanaka S, Kawaguchi H . Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study. Mod Rheumatol. 2014; 24(2):236-42. DOI: 10.3109/14397595.2013.854055. View

Fryar C, Carroll M, Gu Q, Afful J, Ogden C . Anthropometric Reference Data for Children and Adults: United States, 2015-2018. Vital Health Stat 3. 2021; (36):1-44. View

Suzuki T, Nishita Y, Jeong S, Shimada H, Otsuka R, Kondo K . Are Japanese Older Adults Rejuvenating? Changes in Health-Related Measures Among Older Community Dwellers in the Last Decade. Rejuvenation Res. 2020; 24(1):37-48. PMC: 7891218. DOI: 10.1089/rej.2019.2291. View

Yoshimura N, Iidaka T, Horii C, Muraki S, Oka H, Kawaguchi H . Trends in osteoporosis prevalence over a 10-year period in Japan: the ROAD study 2005-2015. J Bone Miner Metab. 2022; 40(5):829-838. DOI: 10.1007/s00774-022-01352-4. View

Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H . Fully automatic quantification of knee osteoarthritis severity on plain radiographs. Osteoarthritis Cartilage. 2008; 16(11):1300-6. DOI: 10.1016/j.joca.2008.03.011. View

10.

Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T . Cohort profile: research on Osteoarthritis/Osteoporosis Against Disability study. Int J Epidemiol. 2009; 39(4):988-95. DOI: 10.1093/ije/dyp276. View

11.

Vitaloni M, Bemden A, Sciortino Contreras R, Scotton D, Bibas M, Quintero M . Global management of patients with knee osteoarthritis begins with quality of life assessment: a systematic review. BMC Musculoskelet Disord. 2019; 20(1):493. PMC: 6815415. DOI: 10.1186/s12891-019-2895-3. View

12.

Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M . Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab. 2009; 27(5):620-8. DOI: 10.1007/s00774-009-0080-8. View

13.

Ratzlaff C, Ashbeck E, Guermazi A, Roemer F, Duryea J, Kwoh C . A quantitative metric for knee osteoarthritis: reference values of joint space loss. Osteoarthritis Cartilage. 2018; 26(9):1215-1224. PMC: 6098736. DOI: 10.1016/j.joca.2018.05.014. View

14.

Teichtahl A, Wluka A, Strauss B, Wang Y, Berry P, Davies-Tuck M . The associations between body and knee height measurements and knee joint structure in an asymptomatic cohort. BMC Musculoskelet Disord. 2012; 13:19. PMC: 3306748. DOI: 10.1186/1471-2474-13-19. View

15.

Kellgren J, Lawrence J . Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16(4):494-502. PMC: 1006995. DOI: 10.1136/ard.16.4.494. View

16.

Oka H, Muraki S, Akune T, Nakamura K, Kawaguchi H, Yoshimura N . Normal and threshold values of radiographic parameters for knee osteoarthritis using a computer-assisted measuring system (KOACAD): the ROAD study. J Orthop Sci. 2010; 15(6):781-9. DOI: 10.1007/s00776-010-1545-2. View

17.

Muraki S, Oka H, Akune T, En-Yo Y, Yoshida M, Nakamura K . Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee: the ROAD study (OAC5914R2). Osteoarthritis Cartilage. 2011; 19(7):840-6. DOI: 10.1016/j.joca.2011.03.008. View

18.

Alnahdi A, Zeni J, Snyder-Mackler L . Muscle impairments in patients with knee osteoarthritis. Sports Health. 2012; 4(4):284-92. PMC: 3435919. DOI: 10.1177/1941738112445726. View