Lipotoxicity and Immunometabolism in Ischemic Acute Kidney Injury: Current Perspectives and Future Directions

Overview

Journal Front Pharmacol

Date 2024 Mar 11

PMID 38464721

Authors

Afolarin A Otunla

Kumaran Shanmugarajah

Alun H Davies

Joseph Shalhoub

Affiliations

Soon will be listed here.

Abstract

Dysregulated lipid metabolism is implicated in the pathophysiology of a range of kidney diseases. The specific mechanisms through which lipotoxicity contributes to acute kidney injury (AKI) remain poorly understood. Herein we review the cardinal features of lipotoxic injury in ischemic kidney injury; lipid accumulation and mitochondrial lipotoxicity. We then explore a new mechanism of lipotoxicity, what we define as "immunometabolic" lipotoxicity, and discuss the potential therapeutic implications of targeting this lipotoxicity using lipid lowering medications.

Citing Articles

Roles of lipid droplets and related proteins in metabolic diseases.

Zhang Z, Yu Z, Liang D, Song K, Kong X, He M Lipids Health Dis. 2024; 23(1):218.

PMID: 39030618 PMC: 11264848. DOI: 10.1186/s12944-024-02212-y.

Editorial: Recent advances in immunometabolism.

Jeelani I, Nawaz A, Asif H, Ahmad I, Gattu A Front Pharmacol. 2024; 15:1422816.

PMID: 38966551 PMC: 11222630. DOI: 10.3389/fphar.2024.1422816.

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