Unmet Needs in Biomarkers for Autoimmune Pancreatitis Diagnosis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2024 Mar 11

PMID 38463027

Authors

Bao-Can Wang

Jian-Gao Fan

Affiliations

Soon will be listed here.

Abstract

Autoimmune pancreatitis (AIP) is a rare chronic autoimmune disorder. The diagnosis of AIP mainly depends on histopathology, imaging and response to treatment. Serum immunoglobulin 4 (IgG4) is used only as collateral evidence in diagnostic criteria for AIP because of its moderate sensitivity. Serum IgG4 levels are normal in 15%-37% of type 1 AIP and most of type 2 AIP patients. In these patients, the indeterminate imaging and histopathology may lead to the difficulty in definitive diagnosis of AIP. Therefore, discovery of new biomarkers is important for AIP diagnosis. Here, we provide some views on the progression and challenges in identifying novel serological biomarkers in AIP diagnosis.

References

Caba O, Dieguez-Castillo C, Martinez-Galan J, Gonzalez-Cebrian I, Jimenez-Luna C . Serum biomarkers for the differentiation of autoimmune pancreatitis from pancreatic ductal adenocarcinoma. World J Gastrointest Oncol. 2023; 15(2):268-275. PMC: 9994052. DOI: 10.4251/wjgo.v15.i2.268. View

Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N . Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci. 1995; 40(7):1561-8. DOI: 10.1007/BF02285209. View

Yamamoto M, Takano K, Kamekura R, Suzuki C, Ichimiya S, Himi T . Stage classification of IgG4-related dacryoadenitis and sialadenitis by the serum cytokine environment. Mod Rheumatol. 2018; 28(6):1004-1008. DOI: 10.1080/14397595.2018.1436029. View

Hubers L, Vos H, Schuurman A, Erken R, Elferink R, Burgering B . Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease. Gut. 2017; 67(4):728-735. DOI: 10.1136/gutjnl-2017-314548. View

Perugino C, AlSalem S, Mattoo H, Della-Torre E, Mahajan V, Ganesh G . Identification of galectin-3 as an autoantigen in patients with IgG-related disease. J Allergy Clin Immunol. 2018; 143(2):736-745.e6. PMC: 6265117. DOI: 10.1016/j.jaci.2018.05.011. View

Shimosegawa T, Chari S, Frulloni L, Kamisawa T, Kawa S, Mino-Kenudson M . International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas. 2011; 40(3):352-8. DOI: 10.1097/MPA.0b013e3182142fd2. View

Matsubayashi H, Uesaka K, Kanemoto H, Asakura K, Kakushima N, Tanaka M . Soluble IL-2 receptor, a new marker for autoimmune pancreatitis. Pancreas. 2012; 41(3):493-6. DOI: 10.1097/MPA.0b013e31823a0d4c. View

Detlefsen S, de Vos J, Tanassi J, Heegaard N, Fristrup C, de Muckadell O . Value of anti-plasminogen binding peptide, anti-carbonic anhydrase II, immunoglobulin G4, and other serological markers for the differentiation of autoimmune pancreatitis and pancreatic cancer. Medicine (Baltimore). 2018; 97(31):e11641. PMC: 6081052. DOI: 10.1097/MD.0000000000011641. View

Umehara H, Okazaki K, Kawa S, Takahashi H, Goto H, Matsui S . The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. Mod Rheumatol. 2020; 31(3):529-533. DOI: 10.1080/14397595.2020.1859710. View

10.

Ikemune M, Uchida K, Tsukuda S, Ito T, Nakamaru K, Tomiyama T . Serum free light chain assessment in type 1 autoimmune pancreatitis. Pancreatology. 2021; 21(3):658-665. DOI: 10.1016/j.pan.2021.03.001. View

11.

Lee S, Yang C, Chang C, Yu K . Diagnostic Utility of Serum IgG4 in Autoimmune Pancreatitis: An Updated Comprehensive Systematic Review and Meta-analysis. J Clin Gastroenterol. 2021; 56(9):810-817. DOI: 10.1097/MCG.0000000000001612. View

12.

Sanchez Castanon M, Zuliani V, Amodio A, Campagnola P, Granato A, Gabbrielli A . Role of Amylase-α2A Autoantibodies in the Diagnosis of Autoimmune Pancreatitis. Pancreas. 2015; 44(7):1078-82. DOI: 10.1097/MPA.0000000000000417. View

13.

Zhou G, Zeng J, Wang L, Liu M, Meng K, Wang Z . Clinical characteristics and outcome of autoimmune pancreatitis based on serum immunoglobulin G4 level: A single-center, retrospective cohort study. World J Gastroenterol. 2023; 29(35):5125-5137. PMC: 10514754. DOI: 10.3748/wjg.v29.i35.5125. View

14.

Shiokawa M, Kodama Y, Sekiguchi K, Kuwada T, Tomono T, Kuriyama K . Laminin 511 is a target antigen in autoimmune pancreatitis. Sci Transl Med. 2018; 10(453). DOI: 10.1126/scitranslmed.aaq0997. View

15.

Tsukuda S, Ikeura T, Ito T, Nakamaru K, Masuda M, Hori Y . Clinical implications of elevated serum interleukin-6 in IgG4-related disease. PLoS One. 2020; 15(1):e0227479. PMC: 6968836. DOI: 10.1371/journal.pone.0227479. View

16.

Kiyoshita Y, Ishii Y, Serikawa M, Hanada K, Sasaki T, Fujimoto Y . Relapse rate and predictors of relapse after cessation of glucocorticoid maintenance therapy in type 1 autoimmune pancreatitis: a multicenter retrospective study. BMC Gastroenterol. 2023; 23(1):295. PMC: 10478447. DOI: 10.1186/s12876-023-02939-5. View

17.

Minaga K, Watanabe T, Hara A, Kamata K, Omoto S, Nakai A . Identification of serum IFN-α and IL-33 as novel biomarkers for type 1 autoimmune pancreatitis and IgG4-related disease. Sci Rep. 2020; 10(1):14879. PMC: 7495433. DOI: 10.1038/s41598-020-71848-4. View

18.

Du H, Shi L, Chen P, Yang W, Xun Y, Yang C . Prohibitin Is Involved in Patients with IgG4 Related Disease. PLoS One. 2015; 10(5):e0125331. PMC: 4416882. DOI: 10.1371/journal.pone.0125331. View

19.

Furukawa S, Moriyama M, Miyake K, Nakashima H, Tanaka A, Maehara T . Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease. Sci Rep. 2017; 7:42413. PMC: 5304322. DOI: 10.1038/srep42413. View

20.

Nishimori I, Morita M, Okazaki K, Yamamoto Y, Onishi S, Hollingsworth M . Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjögren's syndrome. Gastroenterology. 1996; 110(5):1579-86. DOI: 10.1053/gast.1996.v110.pm8613065. View