Automated Radiosynthesis of [F]DPA-714 on a Commercially Available IBA Synthera®

Overview

Journal Appl Radiat Isot

Specialties Environmental Health
Nuclear Medicine

Date 2024 Mar 10

PMID 38461627

Authors

Amy L Vavere

Arijit Ghosh

Victor Amador Diaz

Allison J Clay

Peter M Hall

Kiel D Neumann

Affiliations

Soon will be listed here.

Abstract

The goal of this work was to develop a reliable method to produce the well-validated microglial activation PET tracer, [F]DPA-714, routinely for clinical and preclinical research using an IBA Synthera®. Optimization of literature methods included reduced precursor mass and use of TBA HCO as the phase transfer agent in place of Kryptofix® 222 in a 65-min synthesis with an average activity yield of 24.6 ± 3.8% (n = 5). Successful quality control testing and process validation results are reported.

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