Chlorogenic Acid Prevents Ovariectomized-induced Bone Loss by Facilitating Osteoblast Functions and Suppressing Osteoclast Formation

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2024 Mar 10

PMID 38461437

Authors

Chien-Yi Ho

Chih-Hsin Tang

Trung-Loc Ho

Wen-Ling Wang

Chun-Hsu Yao

Affiliations

Soon will be listed here.

Abstract

Osteoporosis is a usual bone disease in aging populations, principally in postmenopausal women. Anti-resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are associated to a different of adverse effects. Du-Zhong is usually applied in Traditional Chinese Medicine to strengthen bone, regulate bone metabolism, and treat osteoporosis. Chlorogenic acid is a major polyphenol in Du-Zhong. In the current study, chlorogenic acid was found to enhance osteoblast proliferation and differentiation. Chlorogenic acid also inhibits the RANKL-induced osteoclastogenesis. Notably, ovariectomy significantly decreased bone volume and mechanical properties in the ovariectomized (OVX) rats. Administration of chlorogenic acid antagonized OVX-induced bone loss. Taken together, chlorogenic acid seems to be a hopeful molecule for the development of novel anti-osteoporosis treatment.

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References

Zhao H, Zhao N, Zheng P, Xu X, Liu M, Luo D . Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation. J Immunol Res. 2018; 2018:6345857. PMC: 5838472. DOI: 10.1155/2018/6345857. View

Lin J, Fan Y, Mehl C, Zhu J, Chen H, Jin L . Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9. J Zhejiang Univ Sci B. 2011; 12(1):47-54. PMC: 3017416. DOI: 10.1631/jzus.B1000057. View

Qi S, Zheng H, Chen C, Jiang H . Du-Zhong (Eucommia ulmoides Oliv.) Cortex Extract Alleviates Lead Acetate-Induced Bone Loss in Rats. Biol Trace Elem Res. 2018; 187(1):172-180. DOI: 10.1007/s12011-018-1362-6. View

Park S, Choi M, Jung U, Kim M, Kim D, Park H . Eucommia ulmoides Oliver leaf extract increases endogenous antioxidant activity in type 2 diabetic mice. J Med Food. 2007; 9(4):474-9. DOI: 10.1089/jmf.2006.9.474. View

Do M, Hur J, Choi J, Kim M, Kim M, Kim Y . Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney. Nutrients. 2018; 10(3). PMC: 5872683. DOI: 10.3390/nu10030265. View

Rakshit S, Mandal L, Pal B, Bagchi J, Biswas N, Chaudhuri J . Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells. Biochem Pharmacol. 2010; 80(11):1662-75. DOI: 10.1016/j.bcp.2010.08.013. View

Kamiyama M, Moon J, Jang H, Shibamoto T . Role of degradation products of chlorogenic acid in the antioxidant activity of roasted coffee. J Agric Food Chem. 2015; 63(7):1996-2005. DOI: 10.1021/jf5060563. View

Baron R, Hesse E . Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives. J Clin Endocrinol Metab. 2012; 97(2):311-25. PMC: 3275361. DOI: 10.1210/jc.2011-2332. View

Cho A, Jeon S, Kim M, Yeo J, Seo K, Choi M . Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol. 2010; 48(3):937-43. DOI: 10.1016/j.fct.2010.01.003. View

10.

Che C, Wong M, Kei Lam C . Natural Products from Chinese Medicines with Potential Benefits to Bone Health. Molecules. 2016; 21(3):239. PMC: 6274145. DOI: 10.3390/molecules21030239. View

11.

Boyle W, Simonet W, Lacey D . Osteoclast differentiation and activation. Nature. 2003; 423(6937):337-42. DOI: 10.1038/nature01658. View

12.

Zhang Z, Shi C, Wang Z . Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha. Nutrients. 2023; 15(13). PMC: 10343257. DOI: 10.3390/nu15132833. View

13.

Wang C, Tang L, He J, Li J, Wang Y . Ethnobotany, Phytochemistry and Pharmacological Properties of Eucommia ulmoides: A Review. Am J Chin Med. 2019; 47(2):259-300. DOI: 10.1142/S0192415X19500137. View

14.

Chen Y, Hsue Y, Chang H, Gee M . The association between postmenopausal osteoporosis and kidney-vacuity syndrome in traditional Chinese medicine. Am J Chin Med. 1999; 27(1):25-35. DOI: 10.1142/S0192415X99000057. View

15.

Lee S, Lee J, Kwon Y, Jang H . Anti-Osteoclastic Activity of Artemisia capillaris Thunb. Extract Depends upon Attenuation of Osteoclast Differentiation and Bone Resorption-Associated Acidification Due to Chlorogenic Acid, Hyperoside, and Scoparone. Int J Mol Sci. 2017; 18(2). PMC: 5343858. DOI: 10.3390/ijms18020322. View

16.

Khosla S, Hofbauer L . Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 2017; 5(11):898-907. PMC: 5798872. DOI: 10.1016/S2213-8587(17)30188-2. View

17.

Wu L, Ling Z, Feng X, Mao C, Xu Z . Herb Medicines against Osteoporosis: Active Compounds & Relevant Biological Mechanisms. Curr Top Med Chem. 2016; 17(15):1670-1691. DOI: 10.2174/1568026617666161116141033. View

18.

Zhang R, Liu Z, Li C, Hu S, Liu L, Wang J . Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats. Bone. 2008; 45(3):553-9. DOI: 10.1016/j.bone.2008.08.127. View

19.

Han D, Chen W, Gu X, Shan R, Zou J, Liu G . Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Oncotarget. 2017; 8(9):14680-14692. PMC: 5362435. DOI: 10.18632/oncotarget.14747. View

20.

Chen P, Liu J, Fong Y, Huang Y, Chao C, Tang C . CCN3 Facilitates Runx2 and Osterix Expression by Inhibiting miR-608 through PI3K/Akt Signaling in Osteoblasts. Int J Mol Sci. 2019; 20(13). PMC: 6651805. DOI: 10.3390/ijms20133300. View